Pineal-induced ovarian atrophy in rats treated neonatally with testosterone

Russel J. Reiter; Peter H. Rubin; John R. Richert

doi:10.1016/0024-3205(68)90203-8

Pineal-induced ovarian atrophy in rats treated neonatally with testosterone

Russel J. Reiter, Peter H. Rubin, John R. Richert

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Blinding 2 or 3 day old rats decreased uterine weights when animals were killed at 75 days of age; the effect of blinding was counteracted by pinealectomy. TP-treatment at 3 days of age reduced ovarian, but not uterine, size at 75 days of age. This decrease was not prevented by pinealectomy. The combination of blinding and TP-treatment caused marked reductions in the size of both the ovaries and uteri; if these rats were pinealectomized the ovaries and uteri returned to the levels of similar organs in TP-treated animals.

Original language	English (US)
Pages (from-to)	299-305
Number of pages	7
Journal	Life Sciences
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(68)90203-8
State	Published - Mar 1 1968
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "Blinding 2 or 3 day old rats decreased uterine weights when animals were killed at 75 days of age; the effect of blinding was counteracted by pinealectomy. TP-treatment at 3 days of age reduced ovarian, but not uterine, size at 75 days of age. This decrease was not prevented by pinealectomy. The combination of blinding and TP-treatment caused marked reductions in the size of both the ovaries and uteri; if these rats were pinealectomized the ovaries and uteri returned to the levels of similar organs in TP-treated animals.",

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AU - Rubin, Peter H.

AU - Richert, John R.

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Y1 - 1968/3/1

N2 - Blinding 2 or 3 day old rats decreased uterine weights when animals were killed at 75 days of age; the effect of blinding was counteracted by pinealectomy. TP-treatment at 3 days of age reduced ovarian, but not uterine, size at 75 days of age. This decrease was not prevented by pinealectomy. The combination of blinding and TP-treatment caused marked reductions in the size of both the ovaries and uteri; if these rats were pinealectomized the ovaries and uteri returned to the levels of similar organs in TP-treated animals.

AB - Blinding 2 or 3 day old rats decreased uterine weights when animals were killed at 75 days of age; the effect of blinding was counteracted by pinealectomy. TP-treatment at 3 days of age reduced ovarian, but not uterine, size at 75 days of age. This decrease was not prevented by pinealectomy. The combination of blinding and TP-treatment caused marked reductions in the size of both the ovaries and uteri; if these rats were pinealectomized the ovaries and uteri returned to the levels of similar organs in TP-treated animals.

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Pineal-induced ovarian atrophy in rats treated neonatally with testosterone

Abstract

ASJC Scopus subject areas

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