Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland

Dun Xian Tan, Bing Xu, Xinjia Zhou, Russel J. Reiter

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact and functional pineal gland is necessary for preserving optimal human health. Unfortunately, this gland has the highest calcification rate among all organs and tissues of the human body. Pineal calcification jeopardizes melatonin's synthetic capacity and is associated with a variety of neuronal diseases. In the current review, we summarized the potential mechanisms of how this process may occur under pathological conditions or during aging. We hypothesized that pineal calcification is an active process and resembles in some respects of bone formation. The mesenchymal stem cells and melatonin participate in this process. Finally, we suggest that preservation of pineal health can be achieved by retarding its premature calcification or even rejuvenating the calcified gland.

Original languageEnglish (US)
Article number301
JournalMolecules
Volume23
Issue number2
DOIs
StatePublished - 2018

Keywords

  • Aging
  • Calcification
  • Melatonin
  • Neurodegenerative diseases
  • Pineal gland
  • Rejuvenation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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