Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active Surveillance

Crisann Moon, Amber M. Gallegos, Bilal Sheikh, Pratap Kumar, Michael Liss, Darpan I. Patel

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objectives: This study aimed to demonstrate potential translation of pre-clinical studies to a home-based exercise intervention in mediating inflammatory cytokine markers and tumor progression in men under active surveillance for prostate cancer. Methods: A 2-arm randomized control parallel group design was used. The exercise intervention consisted of 24 weeks of an aerobic and resistance home-based exercise program and results were compared to a waitlist control group. Data were collected at baseline and end of study for eotaxin, interferon-γ (INF-γ), interleukin-12 (IL-12), interleukin-1α (IL-1α), interleukin-5 (IL-5), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF), distanced walked during a 6-minute walk test (6MWT), body mass index, and health-related quality of life. Results: Non-significant decreases were observed in all biomarkers, especially VEGF (pre: 125.16 ± 198.66, post: 80.29 ± 124.30, P =.06) and INF-γ (pre: 152.88 ± 312.71, post: 118.93 ± 158.79, P =.08), in the intervention group; only IL- α (pre: 332.15 ± 656.77, post: 255.12 ± 502.09, P =.20) decreased in the control group while all other biomarkers increased from baseline to end of study. A non-significant increase in 6MWT distance was observed in the intervention group, while a decrease was seen in the control group. Significant decreases in physical function, emotional wellbeing, and total composite scale on the FACIT-F were observed in the intervention group, possibly due to the isolation restrictions of COVID-19. Physical function on the SF-36 significantly increased in the control group. Conclusions: Future studies with powered samples are needed to confirm the trends observed for inflammatory biomarkers and functional fitness.

Original languageEnglish (US)
JournalCancer Control
Volume29
DOIs
StatePublished - Sep 2022

Keywords

  • active surveillance
  • biomarker
  • exercise
  • prostate cancer
  • quality of life

ASJC Scopus subject areas

  • Hematology
  • Oncology

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