Abstract
Background: Ion channels are candidate molecules for transforming external stimuli into neural activity during sensory perception. Results: Pickpocket1 encodes an acid-sensing ion channel (ASIC) that is sufficient to drive neural activity in sensory neurons. Conclusion: The perception of external acid by Pickpocket1 channels is sufficient to produce phasic sensory neuron activity. Significance: ASIC channels can function as molecular sensory transducers in sensory neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39878-39886 |
| Number of pages | 9 |
| Journal | Journal of Biological Chemistry |
| Volume | 287 |
| Issue number | 47 |
| DOIs | |
| State | Published - Nov 16 2012 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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