Pickpocket1 is an ionotropic molecular sensory transducer

Nina Boiko, Volodymyr Kucher, James D. Stockand, Benjamin A. Eaton

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Ion channels are candidate molecules for transforming external stimuli into neural activity during sensory perception. Results: Pickpocket1 encodes an acid-sensing ion channel (ASIC) that is sufficient to drive neural activity in sensory neurons. Conclusion: The perception of external acid by Pickpocket1 channels is sufficient to produce phasic sensory neuron activity. Significance: ASIC channels can function as molecular sensory transducers in sensory neurons.

Original languageEnglish (US)
Pages (from-to)39878-39886
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number47
DOIs
StatePublished - Nov 16 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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