PI3-kinase signaling pathway mediates changes in the structural and functional state of leukocyte membranes under type 1 diabetes mellitus

Mykola Zdioruk; Iryna Brodyak; Viktor Drel; Nataliya Sybirna

PI3-kinase signaling pathway mediates changes in the structural and functional state of leukocyte membranes under type 1 diabetes mellitus

Mykola Zdioruk
, Iryna Brodyak
, Viktor Drel
, Nataliya Sybirna

Research output: Contribution to journal › Article › peer-review

Abstract

The research reveals the lectin-induced leukocyte aggregation abilities in healthy donors and type 1 diabetics. It is shown that PI-3'-kinase participates in signal pathways mediating changes in molecular mechanisms responsible for aggregation and adhesion of leukocytic series blood cells. The obtained results may be used in the development of a test system for diabetic diagnosis.

Original language	English (US)
Pages (from-to)	221-225
Number of pages	5
Journal	Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia
Volume	23
Issue number	2
State	Published - 2010
Externally published	Yes

Keywords

Aggregation activity
Lectins
Leukocyte
Type 1 diabetes mellitus

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Pharmacology

Cite this

PI3-kinase signaling pathway mediates changes in the structural and functional state of leukocyte membranes under type 1 diabetes mellitus. / Zdioruk, Mykola; Brodyak, Iryna; Drel, Viktor et al.
In: Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia, Vol. 23, No. 2, 2010, p. 221-225.

Research output: Contribution to journal › Article › peer-review

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abstract = "The research reveals the lectin-induced leukocyte aggregation abilities in healthy donors and type 1 diabetics. It is shown that PI-3'-kinase participates in signal pathways mediating changes in molecular mechanisms responsible for aggregation and adhesion of leukocytic series blood cells. The obtained results may be used in the development of a test system for diabetic diagnosis.",

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AU - Brodyak, Iryna

AU - Drel, Viktor

AU - Sybirna, Nataliya

PY - 2010

Y1 - 2010

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AB - The research reveals the lectin-induced leukocyte aggregation abilities in healthy donors and type 1 diabetics. It is shown that PI-3'-kinase participates in signal pathways mediating changes in molecular mechanisms responsible for aggregation and adhesion of leukocytic series blood cells. The obtained results may be used in the development of a test system for diabetic diagnosis.

KW - Aggregation activity

KW - Lectins

KW - Leukocyte

KW - Type 1 diabetes mellitus

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IS - 2

ER -

PI3-kinase signaling pathway mediates changes in the structural and functional state of leukocyte membranes under type 1 diabetes mellitus

Abstract

Keywords

ASJC Scopus subject areas

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