PI3-kinase signaling pathway mediates changes in the structural and functional state of leukocyte membranes under type 1 diabetes mellitus

Mykola Zdioruk, Iryna Brodyak, Viktor Drel, Nataliya Sybirna

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The research reveals the lectin-induced leukocyte aggregation abilities in healthy donors and type 1 diabetics. It is shown that PI-3'-kinase participates in signal pathways mediating changes in molecular mechanisms responsible for aggregation and adhesion of leukocytic series blood cells. The obtained results may be used in the development of a test system for diabetic diagnosis.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalAnnales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia
Volume23
Issue number2
StatePublished - 2010
Externally publishedYes

Keywords

  • Aggregation activity
  • Lectins
  • Leukocyte
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Pharmacology

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