TY - JOUR
T1 - Physiological studies on the effects of hormonal imbalance on the CNS - 2. Time course of the effects of extirpation of Pars distalis on the levels of cholesterol in the brain of the frog, Rana cyanophlictis
AU - Nayeemunnisa,
AU - Sheela Rani, C. S.
PY - 1976/9
Y1 - 1976/9
N2 - The levels of cholesterol in the fore, mid and hind brain regions were determined in normal and Pars distalis ablated Rana cyanophlictis, at various time intervals after the operation. The time course of the effects of removal of Pars distalis showed an initial overshoot (shock effect) and a recovery phase leading to a new stabilized stage. In general ablation of Pars distalis resulted in the elevation of the levels of cholesterol during the first week after the operation (P>0·05, 0·001 and 0·001 for the fore, mid and hind brain on the first day after the operation). Regional differences in the magnitude of response were significant. A possible relationship between adrenal steroids and thyroid hormones and cholesterol synthesis is suggested.
AB - The levels of cholesterol in the fore, mid and hind brain regions were determined in normal and Pars distalis ablated Rana cyanophlictis, at various time intervals after the operation. The time course of the effects of removal of Pars distalis showed an initial overshoot (shock effect) and a recovery phase leading to a new stabilized stage. In general ablation of Pars distalis resulted in the elevation of the levels of cholesterol during the first week after the operation (P>0·05, 0·001 and 0·001 for the fore, mid and hind brain on the first day after the operation). Regional differences in the magnitude of response were significant. A possible relationship between adrenal steroids and thyroid hormones and cholesterol synthesis is suggested.
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U2 - 10.1007/BF03045586
DO - 10.1007/BF03045586
M3 - Article
AN - SCOPUS:77951503733
VL - 84
SP - 95
EP - 100
JO - Proceedings of the Indian Academy of Sciences - Section B, Experimental Biology
JF - Proceedings of the Indian Academy of Sciences - Section B, Experimental Biology
SN - 0370-0097
IS - 3
ER -