Physiological studies on the effects of hormonal imbalance on the CNS - 2. Time course of the effects of extirpation of Pars distalis on the levels of cholesterol in the brain of the frog, Rana cyanophlictis

Nayeemunnisa, C. S. Sheela Rani

Research output: Contribution to journalArticle

Abstract

The levels of cholesterol in the fore, mid and hind brain regions were determined in normal and Pars distalis ablated Rana cyanophlictis, at various time intervals after the operation. The time course of the effects of removal of Pars distalis showed an initial overshoot (shock effect) and a recovery phase leading to a new stabilized stage. In general ablation of Pars distalis resulted in the elevation of the levels of cholesterol during the first week after the operation (P>0·05, 0·001 and 0·001 for the fore, mid and hind brain on the first day after the operation). Regional differences in the magnitude of response were significant. A possible relationship between adrenal steroids and thyroid hormones and cholesterol synthesis is suggested.

Original languageEnglish (US)
Pages (from-to)95-100
Number of pages6
JournalProceedings of the Indian Academy of Sciences - Section B
Volume84
Issue number3
DOIs
StatePublished - Sep 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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