Physiological levels of melatonin contribute to the antioxidant capacity of human serum

Soledad Benot, Raimundo Goberna, Russel J Reiter, Sofia Garcia-Mauriño, Carmen Osuna, Juan M. Guerrero

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

This work evaluates whether physiological concentrations of the pineal secretory product melatonin contribute to the total antioxidant status (TAS) of human serum. Day and nighttime serum samples were collected from healthy volunteers ranging from 2 to 89 years of age and used to measure melatonin and TAS. Results showed that both melatonin and TAS in human serum exhibited 24 hr variations with nocturnal peak values at 01:00 hr. Moreover, exposure of volunteers to light at night resulted in clear decreases of both TAS and melatonin. Furthermore, when melatonin was removed from sera collected at night, the TAS value of the sample was reduced to basal daytime values. In aging studies, it was found that nocturnal serum values of TAS and melatonin exhibited maximal values during the first four decades; thereafter, these values decreased as age advanced. In 60-year-old individuals, day/night differences in serum melatonin and TAS levels were clearly diminished, by more than 80%, with these differences being completely abolished in older individuals. Our results suggest that melatonin contributes to the total antioxidative capability of human serum. This antioxidant contribution of melatonin is reduced as age advances correlating with the age-related reduction of melatonin.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalJournal of Pineal Research
Volume27
Issue number1
DOIs
StatePublished - 1999

Fingerprint

Melatonin
Antioxidants
Serum
Volunteers
Healthy Volunteers
Light

Keywords

  • Aging
  • Antiaging
  • Circadian rhythm
  • Oxidative stress
  • Pineal gland

ASJC Scopus subject areas

  • Endocrinology

Cite this

Physiological levels of melatonin contribute to the antioxidant capacity of human serum. / Benot, Soledad; Goberna, Raimundo; Reiter, Russel J; Garcia-Mauriño, Sofia; Osuna, Carmen; Guerrero, Juan M.

In: Journal of Pineal Research, Vol. 27, No. 1, 1999, p. 59-64.

Research output: Contribution to journalArticle

Benot, Soledad ; Goberna, Raimundo ; Reiter, Russel J ; Garcia-Mauriño, Sofia ; Osuna, Carmen ; Guerrero, Juan M. / Physiological levels of melatonin contribute to the antioxidant capacity of human serum. In: Journal of Pineal Research. 1999 ; Vol. 27, No. 1. pp. 59-64.
@article{08235ad798e347bfa25450bea734cfd9,
title = "Physiological levels of melatonin contribute to the antioxidant capacity of human serum",
abstract = "This work evaluates whether physiological concentrations of the pineal secretory product melatonin contribute to the total antioxidant status (TAS) of human serum. Day and nighttime serum samples were collected from healthy volunteers ranging from 2 to 89 years of age and used to measure melatonin and TAS. Results showed that both melatonin and TAS in human serum exhibited 24 hr variations with nocturnal peak values at 01:00 hr. Moreover, exposure of volunteers to light at night resulted in clear decreases of both TAS and melatonin. Furthermore, when melatonin was removed from sera collected at night, the TAS value of the sample was reduced to basal daytime values. In aging studies, it was found that nocturnal serum values of TAS and melatonin exhibited maximal values during the first four decades; thereafter, these values decreased as age advanced. In 60-year-old individuals, day/night differences in serum melatonin and TAS levels were clearly diminished, by more than 80{\%}, with these differences being completely abolished in older individuals. Our results suggest that melatonin contributes to the total antioxidative capability of human serum. This antioxidant contribution of melatonin is reduced as age advances correlating with the age-related reduction of melatonin.",
keywords = "Aging, Antiaging, Circadian rhythm, Oxidative stress, Pineal gland",
author = "Soledad Benot and Raimundo Goberna and Reiter, {Russel J} and Sofia Garcia-Mauri{\~n}o and Carmen Osuna and Guerrero, {Juan M.}",
year = "1999",
doi = "10.1111/j.1600-079X.1999.tb00597.x",
language = "English (US)",
volume = "27",
pages = "59--64",
journal = "Journal of Pineal Research",
issn = "0742-3098",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Physiological levels of melatonin contribute to the antioxidant capacity of human serum

AU - Benot, Soledad

AU - Goberna, Raimundo

AU - Reiter, Russel J

AU - Garcia-Mauriño, Sofia

AU - Osuna, Carmen

AU - Guerrero, Juan M.

PY - 1999

Y1 - 1999

N2 - This work evaluates whether physiological concentrations of the pineal secretory product melatonin contribute to the total antioxidant status (TAS) of human serum. Day and nighttime serum samples were collected from healthy volunteers ranging from 2 to 89 years of age and used to measure melatonin and TAS. Results showed that both melatonin and TAS in human serum exhibited 24 hr variations with nocturnal peak values at 01:00 hr. Moreover, exposure of volunteers to light at night resulted in clear decreases of both TAS and melatonin. Furthermore, when melatonin was removed from sera collected at night, the TAS value of the sample was reduced to basal daytime values. In aging studies, it was found that nocturnal serum values of TAS and melatonin exhibited maximal values during the first four decades; thereafter, these values decreased as age advanced. In 60-year-old individuals, day/night differences in serum melatonin and TAS levels were clearly diminished, by more than 80%, with these differences being completely abolished in older individuals. Our results suggest that melatonin contributes to the total antioxidative capability of human serum. This antioxidant contribution of melatonin is reduced as age advances correlating with the age-related reduction of melatonin.

AB - This work evaluates whether physiological concentrations of the pineal secretory product melatonin contribute to the total antioxidant status (TAS) of human serum. Day and nighttime serum samples were collected from healthy volunteers ranging from 2 to 89 years of age and used to measure melatonin and TAS. Results showed that both melatonin and TAS in human serum exhibited 24 hr variations with nocturnal peak values at 01:00 hr. Moreover, exposure of volunteers to light at night resulted in clear decreases of both TAS and melatonin. Furthermore, when melatonin was removed from sera collected at night, the TAS value of the sample was reduced to basal daytime values. In aging studies, it was found that nocturnal serum values of TAS and melatonin exhibited maximal values during the first four decades; thereafter, these values decreased as age advanced. In 60-year-old individuals, day/night differences in serum melatonin and TAS levels were clearly diminished, by more than 80%, with these differences being completely abolished in older individuals. Our results suggest that melatonin contributes to the total antioxidative capability of human serum. This antioxidant contribution of melatonin is reduced as age advances correlating with the age-related reduction of melatonin.

KW - Aging

KW - Antiaging

KW - Circadian rhythm

KW - Oxidative stress

KW - Pineal gland

UR - http://www.scopus.com/inward/record.url?scp=0032773594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032773594&partnerID=8YFLogxK

U2 - 10.1111/j.1600-079X.1999.tb00597.x

DO - 10.1111/j.1600-079X.1999.tb00597.x

M3 - Article

C2 - 10451025

AN - SCOPUS:0032773594

VL - 27

SP - 59

EP - 64

JO - Journal of Pineal Research

JF - Journal of Pineal Research

SN - 0742-3098

IS - 1

ER -