Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: Mouse models

Andrei A. Kruglov, Anna Kuchmiy, Sergei I. Grivennikov, Alexei V. Tumanov, Dmitry V. Kuprash, Sergei A. Nedospasov

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which targets this single molecule, has enjoyed astounding success in treatment of a growing number of human diseases. However, since TNF mediates unique physiologic functions, in particular those related to host defense, TNF blockade may result in unwanted consequences. Much of our understanding about TNF intrinsic functions in the body, as well as about consequences of its overexpression and ablation, is based on studying phenotypes of various genetically engineered mice. Here we review mouse studies aimed at understanding TNF physiologic functions using transgenic and knockout models, and we discuss additional mouse models that may be helpful in the future.

Original languageEnglish (US)
Pages (from-to)231-244
Number of pages14
JournalCytokine and Growth Factor Reviews
Volume19
Issue number3-4
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Keywords

  • Anti-cytokine therapy
  • Disease models
  • Knockout
  • Transgenic mice

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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