Physiologic, histologic, and neurologic responses to simultaneous bilateral cerebral vessel Doppler imaging at high beam intensity

Leonid Bunegin, Jerry Gelineau, Maurice S. Albin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study evaluates physiological fluid heating during continuous bilateral insonation at 530 mW/cm2 for 8 h in a bench simulation. It also examines the physiologic, histopathologic, and neurologic effects of bilateral Doppler imaging of middle cerebral artery (MCA) blood flow velocity using ultrasonic beams with 530 mW/cm2 intensity in a canine model immediately after and 2 weeks after insonation. In saline-filled containers, instrumented with opposing Doppler probes angled 10 degrees off axis, temperature was recorded at 15-min intervals for approximately g h at the intersection of the Doppler probe axes. Three conditions were tested: 1) an ambient control, 2) continuous bilateral insonation at 530 mW/cm2 per channel with the thermistor in position, and 3) intermittent thermistor insertion. In one group of canines, physiopathologic responses during continuous bilateral insonation of the MCAs for 8 h at 2 MHz and 530 mW/cm2 were studied. Brains were prepared for histologic examination immediately after insonation. Cerebral temperature; arterial, venous, pulmonary artery, and capillary wedge pressures; electrocardiogram; cardiac output; MCA velocity; and arterial blood gases were monitored. In a second group of canines, a neurologic evaluation was performed before and after insonation and again after 2 weeks. Brain tissue was evaluated histologically after the last neurologic examination. Light microscopic study was used for all histologic evaluations. In the bench experiments, a net temperature rise in the fluid of the simulation amounted to 0.0075°C/h in the overlap region after correction for ambient temperature effects and artifact thermistor heating. In canines, brain temperature (after correction for core body temperature changes and artifact heating of the thermistor) rose a mean of 0.2°C (p < 0.05) by the first hour, thereafter unchanging. No significant changes in the physiologic, neurologic, or histologic evaluations were observed in either of the experimental groups.

Original languageEnglish (US)
Pages (from-to)42-48
Number of pages7
JournalJournal of Neurosurgical Anesthesiology
Volume10
Issue number1
StatePublished - Jan 1998

Fingerprint

Nervous System
Canidae
Temperature
Heating
Pulmonary Wedge Pressure
Middle Cerebral Artery
Artifacts
Cerebrovascular Circulation
Brain
Doppler Effect
Body Temperature Changes
Blood Flow Velocity
Neurologic Examination
Ultrasonics
Cardiac Output
Electrocardiography
Gases
Light

Keywords

  • Brain
  • Doppler
  • Heating

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Physiologic, histologic, and neurologic responses to simultaneous bilateral cerebral vessel Doppler imaging at high beam intensity. / Bunegin, Leonid; Gelineau, Jerry; Albin, Maurice S.

In: Journal of Neurosurgical Anesthesiology, Vol. 10, No. 1, 01.1998, p. 42-48.

Research output: Contribution to journalArticle

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