Photoswitchable particles for on-demand degradation and triggered release

Tae Hong Park, Thomas W. Eyster, Joshua M. Lumley, Sangyeul Hwang, Kyung Jin Lee, Asish Misra, Sahar Rahmani, Joerg Lahann

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

On-demand degradable polymer particles are fabricated via electrospraying of a solution of acetal-protected dextran that further includes 2-(4-methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine as a photoacid generator. The illumination of UV light gives rise to photoacid and activates the catalytic deprotection of hydroxyl groups of dextran, leading to controlled dissolution of the microparticles in water.

Original languageEnglish (US)
Pages (from-to)3051-3057
Number of pages7
JournalSmall
Volume9
Issue number18
DOIs
StatePublished - Sep 23 2013
Externally publishedYes

Keywords

  • biopolymers
  • drug delivery
  • electrospinning
  • nanoparticles
  • photoswitching

ASJC Scopus subject areas

  • Biotechnology
  • General Chemistry
  • Biomaterials
  • General Materials Science
  • Engineering (miscellaneous)

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