Photooxidant injury to glucose-6-phosphate dehydrogenase-deficient erythrocytes with bilirubin as the sensitizer - An in vitro study

G. Karthikeyan, A. Narang, S. Majumdar, K. Shivani

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

To evaluate the hypothesis that glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes are more prone to photooxidant injury with bilirubin as the sensitizer, we compared the malonyl dialdehyde (MDA) levels and haematocrit values in 11 G6PD-deficient samples with a bilirubin: albumin molar ratio of 1:2 (10 mg% bilirubin, 2.5 g% albumin) photoexposed at 6 μW cm-2 nm-2 (420-460 nm), with 11 of control samples. Twelve hours after photoexposure the incremental changes in MDA levels (OD units) were higher in G6PD-deficient samples [mean (SE) = 0.230 (0.171) vs 0.075 (0.043), p < 0.01]. Antioxidant drugs may have a protective role while G6PD-deficient neonates undergo phototherapy.

Original languageEnglish (US)
Pages (from-to)321-322
Number of pages2
JournalActa Paediatrica, International Journal of Paediatrics
Volume86
Issue number3
DOIs
StatePublished - Jan 1 1997

Keywords

  • glucose-6-phosphate dehydrogenase
  • lipid peroxidation
  • phototherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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