Photodynamic monotherapy or combination treatment with intravitreal triamcinolone acetonide, bevacizumab or ranibizumab for choroidal neovascularization associated with pathological myopia

Pukhraj Rishi, Ekta Rishi, Anusha Venkataraman, Lingam Gopal, Tarun Sharma, Muna Bhende, Dhanashree Ratra, Pratik Sen, Parveen Sen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This retrospective, interventional case series analyses treatment outcomes in eyes with choroidal neovascularization (CNV) secondary to pathological myopia, managed with photodynamic therapy, (PDT), (Group 1, N = 11), PDT and intravitreal triamcinolone acetonide (4 mg/0.1ml) (Group 2, N = 3), PDT and intravitreal anti-vascular endothelial growth factor (anti-VEGF) bevacizumab 1.25 mg/0.05 ml, ranibizumab 0.5 mg/0.05 ml and reduced-fluence PDT and intravitreal ranibizumab 0.5 mg/0.05 ml (Group 3, N=12). All the patients underwent PDT. Intravitreal injections were repeated as required. SPSS 14 software was used to evaluate the data. Wilcoxon signed ranks test was used to evaluate pre- and post-treatment vision. The Kruskal-Wallis test was used for comparison between the groups. All the groups were statistically comparable. All the eyes showed complete regression of CNV, with a minimum follow-up of six months. All groups had visual improvement; significantly in Group 3 ( p = 0.003). Combination PDT with anti-VEGF agents appeared to be efficacious in eyes with myopic CNV. However, a larger study with a longer follow-up is required to validate these results.

Original languageEnglish (US)
Pages (from-to)242-246
Number of pages5
JournalIndian Journal of Ophthalmology
Volume59
Issue number3
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • Bevacizumab
  • choroidal neovascularization
  • intravitreal injection
  • myopia
  • photodynamic therapy
  • ranibizumab
  • triamcinolone acetonide
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Ophthalmology

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