Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes

Takahisa Furuta, Haruyuki Takemura, Zhi Yong Liao, Gregory J. Aune, Christophe Redon, Olga A. Sedelnikova, Duane R. Pilch, Emmy P. Rogakou, Arkady Celeste, Hua Tang Chen, Andre Nussenzweig, Mirit I. Aladjem, William M. Bonner, Yves Pommier

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