Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

Xin Jin; Donglin Ding; Yuqian Yan; Hui Li; Bo Wang; Linlin Ma; Zhenqing Ye; Tao Ma; Qiang Wu; Daniel N. Rodrigues; Manish Kohli; Rafael Jimenez; Liguo Wang; David W. Goodrich; Johann de Bono; Haidong Dong; Heshui Wu; Runzhi Zhu; Haojie Huang

doi:10.1016/j.molcel.2018.10.034

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

Xin Jin
, Donglin Ding
, Yuqian Yan
, Hui Li
, Bo Wang
, Linlin Ma
, Zhenqing Ye
, Tao Ma
, Qiang Wu
, Daniel N. Rodrigues
, Manish Kohli
, Rafael Jimenez
, Liguo Wang
, David W. Goodrich
, Johann de Bono
, Haidong Dong
, Heshui Wu
, Runzhi Zhu
, Haojie Huang

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

Abstract

RB is known to act as a tumor suppressor by inhibiting E2F transcription factors, and this function is abolished due to its phosphorylation by CDKs. Jin et al. identify a previously uncharacterized tumor suppressor role of CDK4/6-phosphorylated RB in promoting cancer immunity via inhibition of NF-κB transcriptional activity and PD-L1 expression.

Original language	English (US)
Pages (from-to)	22-35.e6
Journal	Molecular Cell
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2018.10.034
State	Published - Jan 3 2019
Externally published	Yes

Keywords

CDK4/6 inhibitor
CHD1
MAP3K7
NF-κB
PD-L1
RB
immunotherapy
phosphorylation
prostate cancer
radiotherapy

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2018.10.034

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Jin, X., Ding, D., Yan, Y., Li, H., Wang, B., Ma, L., Ye, Z., Ma, T., Wu, Q., Rodrigues, D. N., Kohli, M., Jimenez, R., Wang, L., Goodrich, D. W., de Bono, J., Dong, H., Wu, H., Zhu, R., & Huang, H. (2019). Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression. Molecular Cell, 73(1), 22-35.e6. https://doi.org/10.1016/j.molcel.2018.10.034

Jin, X, Ding, D, Yan, Y, Li, H, Wang, B, Ma, L, Ye, Z, Ma, T, Wu, Q, Rodrigues, DN, Kohli, M, Jimenez, R, Wang, L, Goodrich, DW, de Bono, J, Dong, H, Wu, H, Zhu, R & Huang, H 2019, 'Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression', Molecular Cell, vol. 73, no. 1, pp. 22-35.e6. https://doi.org/10.1016/j.molcel.2018.10.034

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title = "Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression",

abstract = "RB is known to act as a tumor suppressor by inhibiting E2F transcription factors, and this function is abolished due to its phosphorylation by CDKs. Jin et al. identify a previously uncharacterized tumor suppressor role of CDK4/6-phosphorylated RB in promoting cancer immunity via inhibition of NF-κB transcriptional activity and PD-L1 expression.",

keywords = "CDK4/6 inhibitor, CHD1, MAP3K7, NF-κB, PD-L1, RB, immunotherapy, phosphorylation, prostate cancer, radiotherapy",

author = "Xin Jin and Donglin Ding and Yuqian Yan and Hui Li and Bo Wang and Linlin Ma and Zhenqing Ye and Tao Ma and Qiang Wu and Rodrigues, \{Daniel N.\} and Manish Kohli and Rafael Jimenez and Liguo Wang and Goodrich, \{David W.\} and \{de Bono\}, Johann and Haidong Dong and Heshui Wu and Runzhi Zhu and Haojie Huang",

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year = "2019",

month = jan,

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doi = "10.1016/j.molcel.2018.10.034",

language = "English (US)",

volume = "73",

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T1 - Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

AU - Jin, Xin

AU - Ding, Donglin

AU - Yan, Yuqian

AU - Li, Hui

AU - Wang, Bo

AU - Ma, Linlin

AU - Ye, Zhenqing

AU - Ma, Tao

AU - Wu, Qiang

AU - Rodrigues, Daniel N.

AU - Kohli, Manish

AU - Jimenez, Rafael

AU - Wang, Liguo

AU - Goodrich, David W.

AU - de Bono, Johann

AU - Dong, Haidong

AU - Wu, Heshui

AU - Zhu, Runzhi

AU - Huang, Haojie

PY - 2019/1/3

Y1 - 2019/1/3

N2 - RB is known to act as a tumor suppressor by inhibiting E2F transcription factors, and this function is abolished due to its phosphorylation by CDKs. Jin et al. identify a previously uncharacterized tumor suppressor role of CDK4/6-phosphorylated RB in promoting cancer immunity via inhibition of NF-κB transcriptional activity and PD-L1 expression.

AB - RB is known to act as a tumor suppressor by inhibiting E2F transcription factors, and this function is abolished due to its phosphorylation by CDKs. Jin et al. identify a previously uncharacterized tumor suppressor role of CDK4/6-phosphorylated RB in promoting cancer immunity via inhibition of NF-κB transcriptional activity and PD-L1 expression.

KW - CDK4/6 inhibitor

KW - CHD1

KW - MAP3K7

KW - NF-κB

KW - PD-L1

KW - RB

KW - immunotherapy

KW - phosphorylation

KW - prostate cancer

KW - radiotherapy

UR - https://www.scopus.com/pages/publications/85059121899

UR - https://www.scopus.com/pages/publications/85059121899#tab=citedBy

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DO - 10.1016/j.molcel.2018.10.034

M3 - Article

C2 - 30527665

AN - SCOPUS:85059121899

SN - 1097-2765

VL - 73

SP - 22-35.e6

JO - Molecular Cell

JF - Molecular Cell

IS - 1

ER -

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

Abstract

Keywords

ASJC Scopus subject areas

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