Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation

Patrick Delmas; Bertrand Coste; Nikita Gamper; Mark S. Shapiro

doi:10.1016/j.neuron.2005.07.001

Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation

Patrick Delmas, Bertrand Coste, Nikita Gamper, Mark S. Shapiro

Department of Cellular & Integrative Physiology

Research output: Contribution to journal › Short survey › peer-review

87 Scopus citations

Abstract

Neuronal Ca²⁺ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct Gβγ modulation of Ca²⁺ channels, a slower Gα_q/11-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca²⁺ channel activity. Here, we discuss their role in Ca²⁺ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called "mysterious" G_q/11-mediated signal.

Original language	English (US)
Pages (from-to)	179-182
Number of pages	4
Journal	Neuron
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2005.07.001
State	Published - Jul 21 2005

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2005.07.001

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abstract = "Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct Gβγ modulation of Ca2+ channels, a slower Gαq/11-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2+ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called {"}mysterious{"} Gq/11-mediated signal.",

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AU - Gamper, Nikita

AU - Shapiro, Mark S.

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AB - Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct Gβγ modulation of Ca2+ channels, a slower Gαq/11-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2+ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called "mysterious" Gq/11-mediated signal.

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Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation

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