Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: A case report and review of literature

Maria Luisa Policarpio-Nicolas, Todd E. Abbott, Alan C. Dalkin, Jane Bennett-Wick, Henry F. Frierson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Oncogenic (tumor-induced) osteomalacia is a rare paraneoplastic syndrome of phosphate wasting that is frequently associated with phosphaturic mesenchymal tumor (PMT). As the cytologic features of this tumor apparently have not been reported, we describe the fine-needle aspiration (FNA) findings for PMT that arose from the gluteal soft tissue in a patient with hypophosphatemia and multiple fractures secondary to osteomalacia. Smears from the computerized tomography (CT)-guided FNA showed groups of spindle cells having elongated nuclei, fine to moderately coarsely granular chromatin, inconspicuous nucleoli, and delicate cytoplasm. Marked nuclear atypia, mitotic figures, and necrosis were absent. The differential diagnosis included a variety of benign and malignant spindle cell neoplasms such as monophasic synovial sarcoma, leiomyoma, peripheral nerve sheath tumor, fibrosarcoma, and, less likely, metastatic melanoma and sarcomatoid carcinoma. The bland-appearing cytologic features of a spindle cell tumor in a patient with osteomalacia should suggest the diagnosis of PMT.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalDiagnostic Cytopathology
Volume36
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

Fingerprint

Fine Needle Biopsy
Neoplasms
Osteomalacia
Nerve Sheath Neoplasms
Hypophosphatemia
Synovial Sarcoma
Paraneoplastic Syndromes
Fibrosarcoma
Leiomyoma
Chromatin
Melanoma
Cytoplasm
Differential Diagnosis
Necrosis
Phosphates
Tomography
Carcinoma

Keywords

  • Core biopsy
  • Cytology
  • Fine-needle aspiration
  • Oncogenic osteomalacia
  • Phosphaturic mesenchymal tumor

ASJC Scopus subject areas

  • Anatomy

Cite this

Policarpio-Nicolas, M. L., Abbott, T. E., Dalkin, A. C., Bennett-Wick, J., & Frierson, H. F. (2008). Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: A case report and review of literature. Diagnostic Cytopathology, 36(2), 115-119. https://doi.org/10.1002/dc.20772

Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy : A case report and review of literature. / Policarpio-Nicolas, Maria Luisa; Abbott, Todd E.; Dalkin, Alan C.; Bennett-Wick, Jane; Frierson, Henry F.

In: Diagnostic Cytopathology, Vol. 36, No. 2, 02.2008, p. 115-119.

Research output: Contribution to journalArticle

Policarpio-Nicolas, ML, Abbott, TE, Dalkin, AC, Bennett-Wick, J & Frierson, HF 2008, 'Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: A case report and review of literature', Diagnostic Cytopathology, vol. 36, no. 2, pp. 115-119. https://doi.org/10.1002/dc.20772
Policarpio-Nicolas, Maria Luisa ; Abbott, Todd E. ; Dalkin, Alan C. ; Bennett-Wick, Jane ; Frierson, Henry F. / Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy : A case report and review of literature. In: Diagnostic Cytopathology. 2008 ; Vol. 36, No. 2. pp. 115-119.
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