Phenotypic changes associated with advancing gestation in maternal and fetal baboon lymphocytes

Luis D. Giavedoni, Natalia Schlabritz-Loutsevitch, Vida L. Hodara, Laura M. Parodi, Gene B. Hubbard, Donald J. Dudley, Thomas J. McDonald, Peter W. Nathanielsz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Baboons are very similar to humans in ontogeny, reproductive physiology, and placentation, and thus serve as an excellent nonhuman primate model for use in both normative and perturbation studies of pregnancy that cannot be performed on pregnant women. However, little is known about the changes induced by normal pregnancy in the maternal and fetal baboon in lymphocyte subset composition, and lymphocyte activation and proliferation. We performed multicolor flow cytometry analysis of peripheral venous blood samples obtained from pregnant baboons at mid-gestation (0.5 G), and from matched fetal heart (FH) and umbilical cord (UC) blood at the end of gestation (0.95 G). Compared with their mothers at 0.95 G, fetal lymphocytes had higher percentages of B and CD4 + T cells, and lower numbers of NK and CD8+ T cells. When comparing pregnant baboons at 0.5 and 0.95 G, we also found that pregnancy induces immune stimulation, measured as higher activation without proliferation of CD8+ T and NK cells in the maternal circulation. Our study adds new data to support the notion of pregnancy-induced immune activation and strengthens the value of the baboon as a nonhuman primate model for studies pertinent to human reproductive physiology, pathology, and vaccination.

Original languageEnglish (US)
Pages (from-to)121-132
Number of pages12
JournalJournal of Reproductive Immunology
Volume64
Issue number1-2
DOIs
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

Papio
Mothers
Lymphocytes
Pregnancy
T-Lymphocytes
Primates
Fetal Heart
Placentation
Lymphocyte Subsets
Lymphocyte Activation
Fetal Blood
Natural Killer Cells
Pregnant Women
Flow Cytometry
Vaccination
Cell Count
Pathology

Keywords

  • Activation
  • Baboon
  • Fetus
  • Lymphocytes
  • Pregnancy

ASJC Scopus subject areas

  • Immunology
  • Reproductive Medicine

Cite this

Giavedoni, L. D., Schlabritz-Loutsevitch, N., Hodara, V. L., Parodi, L. M., Hubbard, G. B., Dudley, D. J., ... Nathanielsz, P. W. (2004). Phenotypic changes associated with advancing gestation in maternal and fetal baboon lymphocytes. Journal of Reproductive Immunology, 64(1-2), 121-132. https://doi.org/10.1016/j.jri.2004.09.001

Phenotypic changes associated with advancing gestation in maternal and fetal baboon lymphocytes. / Giavedoni, Luis D.; Schlabritz-Loutsevitch, Natalia; Hodara, Vida L.; Parodi, Laura M.; Hubbard, Gene B.; Dudley, Donald J.; McDonald, Thomas J.; Nathanielsz, Peter W.

In: Journal of Reproductive Immunology, Vol. 64, No. 1-2, 12.2004, p. 121-132.

Research output: Contribution to journalArticle

Giavedoni, LD, Schlabritz-Loutsevitch, N, Hodara, VL, Parodi, LM, Hubbard, GB, Dudley, DJ, McDonald, TJ & Nathanielsz, PW 2004, 'Phenotypic changes associated with advancing gestation in maternal and fetal baboon lymphocytes', Journal of Reproductive Immunology, vol. 64, no. 1-2, pp. 121-132. https://doi.org/10.1016/j.jri.2004.09.001
Giavedoni LD, Schlabritz-Loutsevitch N, Hodara VL, Parodi LM, Hubbard GB, Dudley DJ et al. Phenotypic changes associated with advancing gestation in maternal and fetal baboon lymphocytes. Journal of Reproductive Immunology. 2004 Dec;64(1-2):121-132. https://doi.org/10.1016/j.jri.2004.09.001
Giavedoni, Luis D. ; Schlabritz-Loutsevitch, Natalia ; Hodara, Vida L. ; Parodi, Laura M. ; Hubbard, Gene B. ; Dudley, Donald J. ; McDonald, Thomas J. ; Nathanielsz, Peter W. / Phenotypic changes associated with advancing gestation in maternal and fetal baboon lymphocytes. In: Journal of Reproductive Immunology. 2004 ; Vol. 64, No. 1-2. pp. 121-132.
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