Phenolic melatonin-related compounds: Their role as chemical protectors against oxidative stress

Annia Galano, Romina Castañeda-Arriaga, Adriana Pérez-González, Dun Xian Tan, Russel J Reiter

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

There is currently no doubt about the serious threat that oxidative stress (OS) poses to human health. Therefore, a crucial strategy to maintain a good health status is to identify molecules capable of offering protection against OS through chemical routes. Based on the known efficiency of the phenolic and melatonin (MLT) families of compounds as antioxidants, it is logical to assume that phenolic MLT-related compounds should be (at least) equally efficient. Unfortunately, they have been less investigated than phenols, MLT and its non-phenolic metabolites in this context. The evidence reviewed here strongly suggests that MLT phenolic derivatives can act as both primary and secondary antioxidants, exerting their protection through diverse chemical routes. They all seem to be better free radical scavengers than MLT and Trolox, while some of them also surpass ascorbic acid and resveratrol. However, there are still many aspects that deserve further investigations for this kind of compounds.

Original languageEnglish (US)
Article number1442
JournalMolecules
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

melatonin
protectors
Oxidative stress
Melatonin
Oxidative Stress
antioxidants
health
Antioxidants
routes
Health
Free Radical Scavengers
ascorbic acid
metabolites
Phenols
Metabolites
phenols
free radicals
Ascorbic Acid
Health Status
Derivatives

Keywords

  • Free radicals
  • Kinetics
  • Metal chelation
  • Reaction mechanisms
  • Scavenging activity
  • Trends in activity

ASJC Scopus subject areas

  • Medicine(all)
  • Organic Chemistry

Cite this

Phenolic melatonin-related compounds : Their role as chemical protectors against oxidative stress. / Galano, Annia; Castañeda-Arriaga, Romina; Pérez-González, Adriana; Tan, Dun Xian; Reiter, Russel J.

In: Molecules, Vol. 21, No. 11, 1442, 01.11.2016.

Research output: Contribution to journalReview article

Galano, Annia ; Castañeda-Arriaga, Romina ; Pérez-González, Adriana ; Tan, Dun Xian ; Reiter, Russel J. / Phenolic melatonin-related compounds : Their role as chemical protectors against oxidative stress. In: Molecules. 2016 ; Vol. 21, No. 11.
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