Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample

Youngsin Jung, Brendon P. Boot, Michelle M. Mielke, Tanis J. Ferman, Yonas E. Geda, Eric McDade, Teresa J.H. Christianson, David S. Knopman, Erik K. St Louis, Michael H. Silber, Ronald C. Petersen, Bradley F. Boeve

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Introduction Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal Olmsted County, Minnesota, residents, aged 70 to 89 years with probable RBD. Here, we examine their progression to dementia and other neurodegenerative phenotypes. Methods Fifteen participants with RBD who were diagnosed with either MCI or PD were longitudinally followed, and their subsequent clinical courses were reviewed. Results Over 6.4 ± 2.9 years, six of the 14 participants with MCI developed additional neurodegenerative signs, five of whom had Lewy body disease features. Four of them progressed to dementia at a mean age 84.8 ± 4.9 years, three of whom met the criteria for probable dementia with Lewy bodies. One subject with PD developed MCI, but not dementia. Discussion Our findings from the population-based sample of Olmsted County, Minnesota, residents suggest that a substantial number of RBD patients tend to develop overt synucleinopathy features over time, and RBD patients who develop MCI and subsequent dementia have clinical features most consistent with dementia with Lewy bodies.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume8
DOIs
StatePublished - 2017

Keywords

  • Dementia with Lewy bodies
  • Mild cognitive impairment
  • Parkinson disease
  • Rapid eye movement sleep behavior disorder
  • Synucleinpathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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    Jung, Y., Boot, B. P., Mielke, M. M., Ferman, T. J., Geda, Y. E., McDade, E., Christianson, T. J. H., Knopman, D. S., St Louis, E. K., Silber, M. H., Petersen, R. C., & Boeve, B. F. (2017). Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8, 127-130. https://doi.org/10.1016/j.dadm.2017.05.004