Abstract
This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that dl-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.
Original language | English (US) |
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Pages (from-to) | 257-259 |
Number of pages | 3 |
Journal | Behavioural Brain Research |
Volume | 19 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1986 |
Keywords
- 2-amino-5-phosphonovalerate
- catalepsy
- excitatory amino acid antagonists
- phencyclidine
- pigeons
ASJC Scopus subject areas
- Behavioral Neuroscience