Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

Wouter Koek; Eduardo Kleer; Pamela J. Mudar; James H. Woods

doi:10.1016/0166-4328(86)90026-4

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

Wouter Koek, Eduardo Kleer, Pamela J. Mudar, James H. Woods

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that dl-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.

Original language	English (US)
Pages (from-to)	257-259
Number of pages	3
Journal	Behavioural Brain Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0166-4328(86)90026-4
State	Published - Mar 1986

Keywords

2-amino-5-phosphonovalerate
catalepsy
excitatory amino acid antagonists
phencyclidine
pigeons

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/0166-4328(86)90026-4

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@article{a8c7b5f6758c4587ae644d95c8641064,

title = "Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate",

abstract = "This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that dl-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.",

keywords = "2-amino-5-phosphonovalerate, catalepsy, excitatory amino acid antagonists, phencyclidine, pigeons",

author = "Wouter Koek and Eduardo Kleer and Mudar, {Pamela J.} and Woods, {James H.}",

note = "Funding Information: This research was supported by a NATO Science Fellowship, awarded to W. K. (on leave of absence from the Department of Psychophysiology, University of Utrecht, The Netherlands) by the Netherlands Organization for the Advancement of Pure Research (Z.W.O.) and by USPHS Grants DA00154 and DA00254. E.K. was supported by a fellowship awarded by the Medical Student Research Program of the University of Michigan Medical School. We thank Richard J. Castello for technical assistance.",

year = "1986",

month = mar,

doi = "10.1016/0166-4328(86)90026-4",

language = "English (US)",

volume = "19",

pages = "257--259",

journal = "Behavioural Brain Research",

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publisher = "Elsevier",

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T1 - Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

AU - Koek, Wouter

AU - Kleer, Eduardo

AU - Mudar, Pamela J.

AU - Woods, James H.

N1 - Funding Information: This research was supported by a NATO Science Fellowship, awarded to W. K. (on leave of absence from the Department of Psychophysiology, University of Utrecht, The Netherlands) by the Netherlands Organization for the Advancement of Pure Research (Z.W.O.) and by USPHS Grants DA00154 and DA00254. E.K. was supported by a fellowship awarded by the Medical Student Research Program of the University of Michigan Medical School. We thank Richard J. Castello for technical assistance.

PY - 1986/3

Y1 - 1986/3

N2 - This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that dl-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.

AB - This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that dl-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.

KW - 2-amino-5-phosphonovalerate

KW - catalepsy

KW - excitatory amino acid antagonists

KW - phencyclidine

KW - pigeons

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