Abstract
This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that dl-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 257-259 |
| Number of pages | 3 |
| Journal | Behavioural Brain Research |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1986 |
| Externally published | Yes |
Keywords
- 2-amino-5-phosphonovalerate
- catalepsy
- excitatory amino acid antagonists
- phencyclidine
- pigeons
ASJC Scopus subject areas
- Behavioral Neuroscience
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Cite this
Koek, W., Kleer, E., Mudar, P. J., & Woods, J. H. (1986). Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate. Behavioural Brain Research, 19(3), 257-259. https://doi.org/10.1016/0166-4328(86)90026-4