Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

Wouter Koek, Eduardo Kleer, Pamela J. Mudar, James H. Woods

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that dl-2-amino-5-phosphonovalerate, a selective NMA antagonist, produces phencyclidine-like catalepsy in pigeons. This finding suggests the possibility that other behavioral actions of phencyclidine-like substances may be mediated in a similar fashion.

Original languageEnglish (US)
Pages (from-to)257-259
Number of pages3
JournalBehavioural Brain Research
Volume19
Issue number3
DOIs
StatePublished - Mar 1986
Externally publishedYes

Keywords

  • 2-amino-5-phosphonovalerate
  • catalepsy
  • excitatory amino acid antagonists
  • phencyclidine
  • pigeons

ASJC Scopus subject areas

  • Behavioral Neuroscience

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