Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate

Wouter Koek; James H. Woods; Paul Ornstein

doi:10.1016/0024-3205(86)90285-7

Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate

Wouter Koek, James H. Woods, Paul Ornstein

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A selective N-methyl-D-aspartate antagonist, DL-2-amino-5-phosphonovalerate, was found to produce PCP-like catalepsy, discriminative stimulus effects, and stereotyped operant responding in pigeons when administered intramuscularly. These results support the hypothesis that the behavioral effects of PCP-like drugs result at least in part from reduced neurotransmission at excitatory amino acid synapses utilizing N-methyl-D-aspartate preferring receptors.

Original language	English (US)
Pages (from-to)	973-978
Number of pages	6
Journal	Life Sciences
Volume	39
Issue number	11
DOIs	https://doi.org/10.1016/0024-3205(86)90285-7
State	Published - Sep 15 1986
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(86)90285-7

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title = "Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate",

abstract = "A selective N-methyl-D-aspartate antagonist, DL-2-amino-5-phosphonovalerate, was found to produce PCP-like catalepsy, discriminative stimulus effects, and stereotyped operant responding in pigeons when administered intramuscularly. These results support the hypothesis that the behavioral effects of PCP-like drugs result at least in part from reduced neurotransmission at excitatory amino acid synapses utilizing N-methyl-D-aspartate preferring receptors.",

author = "Wouter Koek and Woods, {James H.} and Paul Ornstein",

note = "Funding Information: Research was supported by USPHS Grant DA0OI54 from the National Institute on Drug Abuse. We thank B. McLaughlin for manuscript preparation.",

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doi = "10.1016/0024-3205(86)90285-7",

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AU - Koek, Wouter

AU - Woods, James H.

AU - Ornstein, Paul

N1 - Funding Information: Research was supported by USPHS Grant DA0OI54 from the National Institute on Drug Abuse. We thank B. McLaughlin for manuscript preparation.

PY - 1986/9/15

Y1 - 1986/9/15

N2 - A selective N-methyl-D-aspartate antagonist, DL-2-amino-5-phosphonovalerate, was found to produce PCP-like catalepsy, discriminative stimulus effects, and stereotyped operant responding in pigeons when administered intramuscularly. These results support the hypothesis that the behavioral effects of PCP-like drugs result at least in part from reduced neurotransmission at excitatory amino acid synapses utilizing N-methyl-D-aspartate preferring receptors.

AB - A selective N-methyl-D-aspartate antagonist, DL-2-amino-5-phosphonovalerate, was found to produce PCP-like catalepsy, discriminative stimulus effects, and stereotyped operant responding in pigeons when administered intramuscularly. These results support the hypothesis that the behavioral effects of PCP-like drugs result at least in part from reduced neurotransmission at excitatory amino acid synapses utilizing N-methyl-D-aspartate preferring receptors.

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ER -

Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate

Abstract

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