Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity

Wouter Koek; James H. Woods; Kenner C. Rice; Arthur E. Jacobson; Philipp N. Huguenin; Terrence R. Burke

doi:10.1016/0014-2999(84)90070-0

Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity

Wouter Koek, James H. Woods, Kenner C. Rice, Arthur E. Jacobson, Philipp N. Huguenin, Terrence R. Burke

Psychiatry

Research output: Contribution to journal › Article

20 Scopus citations

Abstract

A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and α-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.

Original language	English (US)
Pages (from-to)	635-638
Number of pages	4
Journal	European Journal of Pharmacology
Volume	106
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(84)90070-0
Publication status	Published - Nov 27 1984

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Keywords

Cumulative dosing procedure Phencyclidine Catalepsy Pigeons

ASJC Scopus subject areas

Pharmacology

Cite this

Koek, W., Woods, J. H., Rice, K. C., Jacobson, A. E., Huguenin, P. N., & Burke, T. R. (1984). Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity. European Journal of Pharmacology, 106(3), 635-638. https://doi.org/10.1016/0014-2999(84)90070-0

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10.1016/0014-2999(84)90070-0