TY - JOUR
T1 - Phencyclidine-induced catalepsy in pigeons
T2 - Specificity and stereoselectivity
AU - Koek, Wouter
AU - Woods, James H.
AU - Rice, Kenner C.
AU - Jacobson, Arthur E.
AU - Huguenin, Philipp N.
AU - Burke, Terrence R.
N1 - Funding Information:
* Supported by a NATO Science Fellowship, awarded by the Netherlands Organization for the Advancement of Pure Re-search (Z.W.O.); and to whom all correspondence should be addressed: University of Michigan, Department of Phar-macology, M6322, Medical Science Bldg., Ann Arbor, MI 48109, U.S.A.
PY - 1984/11/27
Y1 - 1984/11/27
N2 - A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and α-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.
AB - A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and α-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.
KW - Cumulative dosing procedure Phencyclidine Catalepsy Pigeons
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U2 - 10.1016/0014-2999(84)90070-0
DO - 10.1016/0014-2999(84)90070-0
M3 - Article
C2 - 6542865
AN - SCOPUS:0021679397
VL - 106
SP - 635
EP - 638
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -