Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity

Wouter Koek, James H. Woods, Kenner C. Rice, Arthur E. Jacobson, Philipp N. Huguenin, Terrence R. Burke

Research output: Contribution to journalArticle

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Abstract

A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and α-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalEuropean Journal of Pharmacology
Volume106
Issue number3
DOIs
Publication statusPublished - Nov 27 1984

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Keywords

  • Cumulative dosing procedure Phencyclidine Catalepsy Pigeons

ASJC Scopus subject areas

  • Pharmacology

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