Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: Potential for prostate cancer management

Rita Ghosh, Heather Graham, Paul Rivas, Xishi James Tan, Katherine Crosby, Shylesh Bhaskaran, John Schoolfield, Jameela Banu, Gabriel Fernandes, I. Tien Yeh, Addanki P. Kumar

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Prostate cancer is the second leading cause of cancer-related deaths in men in Western society. Epidemiological studies suggest that a reduced risk of cancer is associated with the consumption of a phytochemical-rich diet that includes fruits and vegetables. Strategies to delay clinically significant prostate cancer will have a tremendous impact in reducing the overall incidence of prostate cancer as well as improving quality of life for elderly men. Furthermore, the long latency involved in the development of clinically significant prostate cancer provides a plethora of opportunities for its management, especially using prevention approaches. Previous studies from our laboratory show that NexrutineR (bark extract from Phellodendron amurense) prevents prostate tumor development when given prior to the development of high-grade prostatic intraepithelial neoplasia in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. In this study, we investigated the effect on the progression of established tumors in the TRAMP model by administering NexrutineR to 28-week-old TRAMP mice. Efficacy of NexrutineR was determined by histopathological evaluation of the prostate. Our data indicate that NexrutineR inhibited progression of prostate tumors that was correlated with tissue levels of transcription factors nuclear factor kappa B, cyclic-AMP response element-binding protein and phosphorylated CREB. Moreover, NexrutineR intervention resulted in a significant increase in the bone mineral density of the left femur diaphysis (p=0.009) and prevented the development of metastatic lesions. Nexrutine R treatment also significantly (p=0.005) inhibited invasion of androgen-independent prostate cancer cells.

Original languageEnglish (US)
Pages (from-to)857-866
Number of pages10
JournalAnticancer Research
Volume30
Issue number3
StatePublished - Mar 2010

Keywords

  • BMD
  • CREB
  • NF-κB
  • Nexrutine
  • Prostate cancer
  • TRAMP
  • Tumor invasion

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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