Phase II trial of recombinant beta interferon in advanced colorectal cancer

P. K. Lillis, T. D. Brown, K. Beougher, J. Koeller, S. G. Marcus, D. D. Von Hoff

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    Abstract

    Betaseron is a genetically altered recombinant beta interferon with in vitro properties equivalent to those of native beta interferon. Nineteen patients with measurable advanced colorectal carcinoma who had no previous chemotherapy were given 30 x 106 IU Betaseron by iv push on Days 1-5 and 8-12 of each 28-day cycle. One of 17 evaluable patients had a complete response after nine courses of treatment which has been sustained > 9 months. The overall response rate was 6% (95% confidence limits, 0%-18%). Treatment was well tolerated with toxic effects consisting of fever, flu-like symptoms, nausea and vomiting, and transient mild granulocytopenia and liver function abnormalities. All toxic effects were World Health Organization (WHO) grade ≤ 2. No interferon neutralizing antibody activity was detected. Phase I and preclinical data support further investigation of Betaseron with dose escalation to tolerance for individual patients, as well as investigation of concomitant therapy with 5-fluorouracil, in an attempt to improve the observed response rate in colorectal cancer.

    Original languageEnglish (US)
    Pages (from-to)965-967
    Number of pages3
    JournalCancer Treatment Reports
    Volume71
    Issue number10
    StatePublished - Dec 1 1987

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    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this

    Lillis, P. K., Brown, T. D., Beougher, K., Koeller, J., Marcus, S. G., & Von Hoff, D. D. (1987). Phase II trial of recombinant beta interferon in advanced colorectal cancer. Cancer Treatment Reports, 71(10), 965-967.