Phase I clinical trial and pharmacokinetics of carboplatin (nsc 241240) by single monthly 30‐minute infusion

Jim M. Koeller, Donald L. Trump, Kendra D. Tutsch, Robert H. Earhart, Thomas E. Davis, Douglass C. Tormey

    Research output: Contribution to journalArticlepeer-review

    82 Scopus citations

    Abstract

    Carboplatin (diammine[1,1‐cyclobutanedicarboxylate(2‐)‐O,ó]platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty‐two 30‐minute infusions of carboplatin were given to 20 evaluable patients with a variety of solid tumors. Maximum tolerated dose was 440 mg/m2. Thrombocytopenia (<100,000/mm3) occurred in six of seven patients; two patients experienced a leukocyte count less than 2000/mm3. Platelet and leukocyte count nadirs occurred on day 21. No nephrotoxicity was seen. Blood urea nitrogen, serum creatine levels, and creatinine clearances remained normal, and no consistent elevation of urinary β2‐microglobulin, leucine aminopeptidase, or N‐acetyl‐β‐glucosaminidase occurred. Nausea and vomiting were mild to moderate. A single patient developed mild peripheral neuropathy. No auditory toxicity was noted. The recommended dose for Phase II studies is 400 mg/m2 every 28 days for good risk patients; heavily pretreated patients should receive 320 mg/m2.

    Original languageEnglish (US)
    Pages (from-to)222-225
    Number of pages4
    JournalCancer
    Volume57
    Issue number2
    DOIs
    StatePublished - Jan 15 1986

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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