An efficient synthesis of the macrocyclic core of laulimalide with a pendant vinyl group at C20 is described, allowing for late-stage introduction of various side chains through a selective and efficient cross metathesis diversification step. Representative analogues reported herein are the first to contain modifications to only the side chain dihydropyran of laulimalide and des-epoxy laulimalide. This step-economical strategy enables the rapid synthesis of new analogues using alkenes as an inexpensive, abundantly available diversification feedstock.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Aug 31 2006|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry