Pharmacology of peripheral neuropeptide and inflammatory mediator release

Kenneth M. Hargreaves, James Q. Swift, Mark T. Roszkowski, Walter Bowles, Mary G. Garry, Douglass L. Jackson

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Research conducted in the last 10 years has increased our knowledge on pain mechanisms substantially. Although many local tissue mediators, including neuropeptides, are known to exert pro-inflammatory effects, comparatively little is known about the actual tissue levels of these inflammatory mediators and their pharmacologic regulation. This article describes two new methods, clinical microdialysis and superfusion of dental pulp, which provide data on the pharmacology of peripheral neuropeptide and inflammatory mediator release. Collectively, these methods provide a biochemically based approach toward determining the mechanisms and management of orofacial pain.

Original languageEnglish (US)
Pages (from-to)503-510
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology
Issue number4
StatePublished - Oct 1994
Externally publishedYes

ASJC Scopus subject areas

  • General Dentistry
  • Pathology and Forensic Medicine


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