Pharmacology of Antiemetics: Update and Current Considerations in Anesthesia Practice

Alan D. Kaye, Elyse M. Cornett, John Chalabi, Natale Z. Naim, Matthew B. Novitch, Justin B. Creel, Preya Jhita, Thomas N. Trang, Jacquelyn R. Paetzold, Nicholas Darensburg, Burton D. Beakley, Richard D. Urman

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Postoperative nausea and vomiting (PONV) is associated with delayed recovery and dissatisfaction after surgical procedures. A key component to management is identifying risk factors and high-risk populations. Advances in pharmacologic therapeutics have resulted in agents targeting different pathways associated with the mediation of nausea and vomiting. This review focuses on these agents and the clinical aspects of their use in patients postoperatively. Combination therapies are reviewed, and studies demonstrate that when 2 or more antiemetic agents acting on different receptors are used, an overall improved efficacy is demonstrated when compared with a single agent alone in patients.

Original languageEnglish (US)
Pages (from-to)e41-e54
JournalAnesthesiology Clinics
Issue number2
StatePublished - Jun 2017
Externally publishedYes


  • Anesthesia
  • Anticholinergics
  • Antiemetics
  • Dopamine receptor
  • Neurokinin-1 receptor
  • P6 acupuncture point
  • Postoperative nausea and vomiting
  • Serotonin receptor

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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