Pharmacological MRI of the choroid and retina: Blood flow and BOLD responses during nitroprusside infusion

Yen Yu I Shih, Guang Li, Eric R. Muir, Bryan H. De La Garza, Jeffrey W. Kiel, Timothy Q. Duong

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Nitroprusside, a vasodilatory nitric oxide donor, is clinically used during vascular surgery and to lower blood pressure in acute hypertension. This article reports a novel application of blood flow (BF) and blood oxygenation level dependent (BOLD) MRI on an 11.7T scanner to image the rat chorioretinal BF and BOLD changes associated with graded nitroprusside infusion. At low doses (1 or 2 μg/kg/min), nitroprusside increased BF as expected but decreased BOLD signals, showing an intriguing BF-BOLD uncoupling. At high doses (3-5 μg/kg/min), nitroprusside decreased BF and markedly decreased BOLD signals. To our knowledge, this is the first pharmacological MRI application of the retina. This approach has potential to open up new avenues to study the drug-related hemodynamic functions and to evaluate the effects of novel therapeutic interventions on BOLD and BF in the normal and diseased retinas. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalMagnetic Resonance in Medicine
Volume68
Issue number4
DOIs
StatePublished - Oct 2012

Keywords

  • blood flow
  • blood oxygenation level dependent
  • nitric oxide
  • nitroprusside
  • pharmacological MRI
  • retina

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Shih, Y. Y. I., Li, G., Muir, E. R., De La Garza, B. H., Kiel, J. W., & Duong, T. Q. (2012). Pharmacological MRI of the choroid and retina: Blood flow and BOLD responses during nitroprusside infusion. Magnetic Resonance in Medicine, 68(4), 1273-1278. https://doi.org/10.1002/mrm.24112