Pharmacological characterization of the discriminative stimulus properties of the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)- cyclohexyl]piperidine

Mark S. Kleven, Jean Marc Kamenka, Jacques Vignon, Wouter Koek

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Rationale: Although both cocaine and the phencyclidine analog, BTCP, have dopamine (DA) re-uptake blocking properties, under some conditions their behavioral effects can be differentiated. Therefore, we examined whether the discriminative stimulus (DS) effects of BTCP are different from those of cocaine. Objectives: To compare the effects of monoamine re-uptake blockers, varying in their in vitro potencies as inhibitors of DA, norepinephrine (NE), or serotonin re-uptake, in different groups of rats trained to discriminate either BTCP or cocaine from saline. Additionally, drugs from other pharmacological classes were tested in both groups. Methods: Rats were trained to discriminate either BTCP (5 mg/kg, i.p.) or cocaine (10 mg/kg, i.p.) from saline under a two-lever FR10 drug discrimination procedure. Results: BTCP and cocaine cross-substituted in BTCP- and cocaine-trained rats. The DA re-uptake blockers, mazindol, indatraline, methylphenidate, GBR12909, and GBR12935, occasioned dose-related drug-lever (DL) selection both in cocaine-and in BTCP-trained rats, with potencies that were significantly correlated. In contrast, the NE re-uptake blockers, nisoxetine, desipramine, and nortriptyline, produced higher levels of DL selection in BTCP-trained rats than in cocaine-trained rats, a profile like that reported in low-dose cocaine-trained rats. Drugs from other classes acted similarly in both discriminations. Further, the α1-adrenergic antagonist prazosin dose dependently blocked the DS effects of the training dose of BTCP, but not of cocaine. Conclusions: The results suggest that the DS effects of BTCP are similar to cocaine, and resemble those of a low training dose of cocaine.

Original languageEnglish (US)
Pages (from-to)370-377
Number of pages8
JournalPsychopharmacology
Volume145
Issue number4
DOIs
StatePublished - Sep 17 1999
Externally publishedYes

Keywords

  • BTCP
  • Cocaine
  • Dopamine
  • Drug discrimination
  • Monoamine re-uptake blocker
  • Norepinephrine
  • Prazosin

ASJC Scopus subject areas

  • Pharmacology

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