Abstract
Objective: The purpose of this study was to evaluate clinical outcomes associated with the initiation of treatment for urgency-predominant incontinence in women diagnosed by a simple 3-item questionnaire. Study Design: We conducted a multicenter, double-blinded, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence in ambulatory women diagnosed by the simple 3-item questionnaire. Participants (N = 645) were assigned randomly to fesoterodine therapy (4-8 mg daily) or placebo. Urinary incontinence was assessed with the use of voiding diaries; postvoid residual volume was measured after treatment. Results: After 12 weeks, women who had been assigned randomly to fesoterodine therapy reported 0.9 fewer urgency and 1.0 fewer total incontinence episodes/day, compared with placebo (P ≤.001). Four serious adverse events occurred in each group, none of which was related to treatment. No participant had postvoid residual volume of <250 mL after treatment. Conclusion: Among ambulatory women with urgency-predominant incontinence diagnosed with a simple 3-item questionnaire, pharmacologic therapy resulted in a moderate decrease in incontinence frequency without increasing significant urinary retention or serious adverse events, which provides support for a streamlined algorithm for diagnosis and treatment of female urgency-predominant incontinence.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 206 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2012 |
Fingerprint
Keywords
- antimuscarinic therapy
- diagnostic algorithm
- fesoterodine
- urgency incontinence
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Pharmacologic treatment for urgency-predominant urinary incontinence in women diagnosed using a simplified algorithm : A randomized trial. / Huang, Alison J.; Hess, Rachel; Arya, Lily A.; Richter, Holly E.; Subak, Leslee L.; Bradley, Catherine S.; Rogers, Rebecca G.; Myers, Deborah L.; Johnson, Karen C.; Gregory, W. Thomas; Kraus, Stephen R; Schembri, Michael; Brown, Jeanette S.
In: American Journal of Obstetrics and Gynecology, Vol. 206, No. 5, 05.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacologic treatment for urgency-predominant urinary incontinence in women diagnosed using a simplified algorithm
T2 - A randomized trial
AU - Huang, Alison J.
AU - Hess, Rachel
AU - Arya, Lily A.
AU - Richter, Holly E.
AU - Subak, Leslee L.
AU - Bradley, Catherine S.
AU - Rogers, Rebecca G.
AU - Myers, Deborah L.
AU - Johnson, Karen C.
AU - Gregory, W. Thomas
AU - Kraus, Stephen R
AU - Schembri, Michael
AU - Brown, Jeanette S.
PY - 2012/5
Y1 - 2012/5
N2 - Objective: The purpose of this study was to evaluate clinical outcomes associated with the initiation of treatment for urgency-predominant incontinence in women diagnosed by a simple 3-item questionnaire. Study Design: We conducted a multicenter, double-blinded, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence in ambulatory women diagnosed by the simple 3-item questionnaire. Participants (N = 645) were assigned randomly to fesoterodine therapy (4-8 mg daily) or placebo. Urinary incontinence was assessed with the use of voiding diaries; postvoid residual volume was measured after treatment. Results: After 12 weeks, women who had been assigned randomly to fesoterodine therapy reported 0.9 fewer urgency and 1.0 fewer total incontinence episodes/day, compared with placebo (P ≤.001). Four serious adverse events occurred in each group, none of which was related to treatment. No participant had postvoid residual volume of <250 mL after treatment. Conclusion: Among ambulatory women with urgency-predominant incontinence diagnosed with a simple 3-item questionnaire, pharmacologic therapy resulted in a moderate decrease in incontinence frequency without increasing significant urinary retention or serious adverse events, which provides support for a streamlined algorithm for diagnosis and treatment of female urgency-predominant incontinence.
AB - Objective: The purpose of this study was to evaluate clinical outcomes associated with the initiation of treatment for urgency-predominant incontinence in women diagnosed by a simple 3-item questionnaire. Study Design: We conducted a multicenter, double-blinded, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence in ambulatory women diagnosed by the simple 3-item questionnaire. Participants (N = 645) were assigned randomly to fesoterodine therapy (4-8 mg daily) or placebo. Urinary incontinence was assessed with the use of voiding diaries; postvoid residual volume was measured after treatment. Results: After 12 weeks, women who had been assigned randomly to fesoterodine therapy reported 0.9 fewer urgency and 1.0 fewer total incontinence episodes/day, compared with placebo (P ≤.001). Four serious adverse events occurred in each group, none of which was related to treatment. No participant had postvoid residual volume of <250 mL after treatment. Conclusion: Among ambulatory women with urgency-predominant incontinence diagnosed with a simple 3-item questionnaire, pharmacologic therapy resulted in a moderate decrease in incontinence frequency without increasing significant urinary retention or serious adverse events, which provides support for a streamlined algorithm for diagnosis and treatment of female urgency-predominant incontinence.
KW - antimuscarinic therapy
KW - diagnostic algorithm
KW - fesoterodine
KW - urgency incontinence
UR - http://www.scopus.com/inward/record.url?scp=84860273398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860273398&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2012.03.002
DO - 10.1016/j.ajog.2012.03.002
M3 - Article
C2 - 22542122
AN - SCOPUS:84860273398
VL - 206
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 5
ER -