Pharmacologic treatment for urgency-predominant urinary incontinence in women diagnosed using a simplified algorithm: A randomized trial

Alison J. Huang, Rachel Hess, Lily A. Arya, Holly E. Richter, Leslee L. Subak, Catherine S. Bradley, Rebecca G. Rogers, Deborah L. Myers, Karen C. Johnson, W. Thomas Gregory, Stephen R. Kraus, Michael Schembri, Jeanette S. Brown

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective: The purpose of this study was to evaluate clinical outcomes associated with the initiation of treatment for urgency-predominant incontinence in women diagnosed by a simple 3-item questionnaire. Study Design: We conducted a multicenter, double-blinded, 12-week randomized trial of pharmacologic therapy for urgency-predominant incontinence in ambulatory women diagnosed by the simple 3-item questionnaire. Participants (N = 645) were assigned randomly to fesoterodine therapy (4-8 mg daily) or placebo. Urinary incontinence was assessed with the use of voiding diaries; postvoid residual volume was measured after treatment. Results: After 12 weeks, women who had been assigned randomly to fesoterodine therapy reported 0.9 fewer urgency and 1.0 fewer total incontinence episodes/day, compared with placebo (P ≤.001). Four serious adverse events occurred in each group, none of which was related to treatment. No participant had postvoid residual volume of <250 mL after treatment. Conclusion: Among ambulatory women with urgency-predominant incontinence diagnosed with a simple 3-item questionnaire, pharmacologic therapy resulted in a moderate decrease in incontinence frequency without increasing significant urinary retention or serious adverse events, which provides support for a streamlined algorithm for diagnosis and treatment of female urgency-predominant incontinence.

Original languageEnglish (US)
Pages (from-to)444.e1-444.e11
JournalAmerican Journal of Obstetrics and Gynecology
Volume206
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • antimuscarinic therapy
  • diagnostic algorithm
  • fesoterodine
  • urgency incontinence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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