Pharmacokinetics properties of surface-modified vesicles

Keitaro Sou, Beth Coins, William T Phillips, Shinji Takeoka, Eishun Tsuchida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Phospholipid vesicles, also called liposome, are potent carriers of various drugs and offer a drug targeting system into specific organs, tissues, or cells, to minimize the drug administration dose and improve the therapeutic safety. Recently, we have found that phospholipid vesicle containing an anionic amphiphile; 1,5-dihexadecyl-L-glutamate-N-succinic acid (Suc-2C 16) and polyethylene glycol)-lipid (PEG-DSPE) are mainly up taken by rabbit bone marrow at a small injection dose (15 mg/kg b.w.). At 24 h after intravenous injection of 99m-technetimu ( 99mTc)-labeled vesicles in rabbit, biodistribution data clearly indicated that the component of Suc-2C 16 induced the significant affinity to bone marrow in comparison with control vesicles, which do not have Suc-2C 16. Further incorporation of as little as 0.6 mol% of PEG-DSPE passively enhanced the distribution of Suc-Ve into bone marrow inhibiting the liver uptake, and this formulation was distributed in the bone marrow over the whole body, reaching to 70% of the injected dose by 6 h after injection.

Original languageEnglish (US)
Title of host publicationPolymer Preprints, Japan
Pages3046-3047
Number of pages2
Volume54
Edition2
StatePublished - 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period9/20/059/22/05

Fingerprint

Pharmacokinetics
Bone
Polyethylene glycols
Phospholipids
Amphiphiles
Liposomes
Liver
Lipids
Tissue
Acids

Keywords

  • Bone marrow
  • Carrier
  • Pharmacokinetics
  • Phospholipid vesicles
  • Poly (ethylene glycol)
  • Surface modification

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sou, K., Coins, B., Phillips, W. T., Takeoka, S., & Tsuchida, E. (2005). Pharmacokinetics properties of surface-modified vesicles. In Polymer Preprints, Japan (2 ed., Vol. 54, pp. 3046-3047)

Pharmacokinetics properties of surface-modified vesicles. / Sou, Keitaro; Coins, Beth; Phillips, William T; Takeoka, Shinji; Tsuchida, Eishun.

Polymer Preprints, Japan. Vol. 54 2. ed. 2005. p. 3046-3047.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sou, K, Coins, B, Phillips, WT, Takeoka, S & Tsuchida, E 2005, Pharmacokinetics properties of surface-modified vesicles. in Polymer Preprints, Japan. 2 edn, vol. 54, pp. 3046-3047, 54th SPSJ Symposium on Macromolecules, Yamagata, Japan, 9/20/05.
Sou K, Coins B, Phillips WT, Takeoka S, Tsuchida E. Pharmacokinetics properties of surface-modified vesicles. In Polymer Preprints, Japan. 2 ed. Vol. 54. 2005. p. 3046-3047
Sou, Keitaro ; Coins, Beth ; Phillips, William T ; Takeoka, Shinji ; Tsuchida, Eishun. / Pharmacokinetics properties of surface-modified vesicles. Polymer Preprints, Japan. Vol. 54 2. ed. 2005. pp. 3046-3047
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