Pharmacokinetics of tcdd in veterans of operation ranch hand: 15-year follow-up

Joel E. Michalek, Ram C. Tripathi

    Research output: Contribution to journalArticlepeer-review

    91 Scopus citations

    Abstract

    Using multiple measurements from serum collected over 15 yr (in 1982, 1987, 1992, and 1997), the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 97 veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam, was estimated. The potential influences of age, percent body fat, and changes in percent body fat on the half-life estimate were also examined. The elimination rate of TCDD for these veterans was 0.0915 per year with 95% confidence interval 0.0844 to 0.0986 per year; the corresponding half-life estimate was 7.6 yr with 95% confidence interval 7.0 to 8.2 yr. The elimination rate decreased significantly with increasing body fat, but not with age or relative changes in percent body fat.

    Original languageEnglish (US)
    Pages (from-to)369-378
    Number of pages10
    JournalJournal of Toxicology and Environmental Health - Part A
    Volume57
    Issue number6
    DOIs
    StatePublished - Jul 1999

    ASJC Scopus subject areas

    • Toxicology
    • Health, Toxicology and Mutagenesis

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