TY - JOUR
T1 - Pharmacokinetics of Melatonin
T2 - The Missing Link in Clinical Efficacy?
AU - Andersen, Lars Peter Holst
AU - Gögenur, Ismail
AU - Rosenberg, Jacob
AU - Reiter, Russel J.
N1 - Publisher Copyright:
© 2016, Springer International Publishing Switzerland.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Despite widespread clinical application of melatonin, several unanswered questions remain regarding the pharmacokinetics of this drug. This lack of knowledge may contribute to the inconsistency of results in previous clinical studies. Currently, a tmax value of 30–45 min and a t½elimination of 45 min are well established. Several questions relate to what constitutes a clinically effective plasma concentration, the choice of ideal administration route, and the optimal method of analysis. Furthermore, investigations of melatonin metabolites in humans are urgently needed in order to characterize their biological functions and the metabolic fates of these derivatives. Finally, pharmacokinetics in patients should be investigated further in order to reduce the risk of potential adverse effects, such as daytime sleepiness or unintended sedation.
AB - Despite widespread clinical application of melatonin, several unanswered questions remain regarding the pharmacokinetics of this drug. This lack of knowledge may contribute to the inconsistency of results in previous clinical studies. Currently, a tmax value of 30–45 min and a t½elimination of 45 min are well established. Several questions relate to what constitutes a clinically effective plasma concentration, the choice of ideal administration route, and the optimal method of analysis. Furthermore, investigations of melatonin metabolites in humans are urgently needed in order to characterize their biological functions and the metabolic fates of these derivatives. Finally, pharmacokinetics in patients should be investigated further in order to reduce the risk of potential adverse effects, such as daytime sleepiness or unintended sedation.
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U2 - 10.1007/s40262-016-0386-3
DO - 10.1007/s40262-016-0386-3
M3 - Article
C2 - 27000757
AN - SCOPUS:84961786426
SN - 0312-5963
VL - 55
SP - 1027
EP - 1030
JO - Clinical Pharmacokinetics
JF - Clinical Pharmacokinetics
IS - 9
ER -