Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand

Joel E Michalek, James L. Pirkle, Larry L. Needham, Donald G. Patterson, Samuel P. Caudill, Ram C. Tripathi, Paolo Mocarelli

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

A combined analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in Seveso adults and Ranch Hand veterans found a period of fast elimination within the first 0.27 years after exposure in Seveso, followed by a period of slower elimination between 3 and 16.35 years from exposure. The mean TCDD elimination rate within the first 0.27 years after exposure among six adult males in the Seveso cohort was 2.0646 year-1 (half-life =0.34 years). The mean rate from 3 to 16.35 years was 0.1011 year-1 (half-life=6.9 years). The mean Ranch Hand elimination rate, 00924 year-1 (half-life=6.9 years), measured between 9 and 33 years after exposure, was significantly less than the Seveso mean in the first 0.27 years after exposure, but not significantly different from the Seveso mean between 3 and 16.35 years after exposure. The fast elimination within the first 0.27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase.

Original languageEnglish (US)
Pages (from-to)44-53
Number of pages10
JournalJournal of Exposure Analysis and Environmental Epidemiology
Volume12
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Pharmacokinetics
Veterans
dioxin
Half-Life
Hand
half life
Polychlorinated Dibenzodioxins
exposure
pharmacokinetics
1,4-dioxin
rate

Keywords

  • Agent Orange
  • Dioxin
  • Pharmacokinetics
  • TCDD

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. / Michalek, Joel E; Pirkle, James L.; Needham, Larry L.; Patterson, Donald G.; Caudill, Samuel P.; Tripathi, Ram C.; Mocarelli, Paolo.

In: Journal of Exposure Analysis and Environmental Epidemiology, Vol. 12, No. 1, 2002, p. 44-53.

Research output: Contribution to journalArticle

Michalek, Joel E ; Pirkle, James L. ; Needham, Larry L. ; Patterson, Donald G. ; Caudill, Samuel P. ; Tripathi, Ram C. ; Mocarelli, Paolo. / Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand. In: Journal of Exposure Analysis and Environmental Epidemiology. 2002 ; Vol. 12, No. 1. pp. 44-53.
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