Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation

Lisbeth A. Welniak, Dmitry V. Kuprash, Alexei V. Tumanov, Angela Panoskaltsis-Mortari, Bruce R. Blazar, Kai Sun, Sergei A. Nedospasov, William J. Murphy

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Graft-versus-host disease (GVHD) is a multistep disease process following allogeneic bone marrow transplantation (BMT). It has been postulated that the induction of acute GVHD requires the presence of Peyer patches (PPs). A new tumor necrosis factor (TNF)-deficient strain has been developed that totally lacks PPs and displays the defects characteristic of TNF ablation but not lymphotoxin-associated defects characterized by lack of both PPs and lymph nodes. To determine the necessity of PPs in acute lethal GVHD induction, we transplanted full major histocompatibility complex (MHC)-mismatched grafts into myeloablated TNF knockout recipients. No differences in the survival or GVHD-associated histopathologic lesions were observed between the recipients. We conclude that neither PPs nor host TNF-α is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT.

Original languageEnglish (US)
Pages (from-to)410-412
Number of pages3
JournalBlood
Volume107
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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