Abstract
We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.
Original language | English (US) |
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Pages (from-to) | 1030-1033 |
Number of pages | 4 |
Journal | Movement Disorders |
Volume | 22 |
Issue number | 7 |
DOIs | |
State | Published - May 15 2007 |
Keywords
- C- flumazenil
- GABA
- Positron emission tomography
- Stiff person syndrome
ASJC Scopus subject areas
- Neurology
- Clinical Neurology