PET evidence of central GABAergic changes in stiff-person syndrome

Daniela Perani; Valentina Garibotto; Andrea Panzacchi; Rosa Maria Moresco; Paola Ortelli; Massimo Corbo; Ferruccio Fazio; Franco Folli

doi:10.1002/mds.21441

PET evidence of central GABAergic changes in stiff-person syndrome

Daniela Perani, Valentina Garibotto, Andrea Panzacchi, Rosa Maria Moresco, Paola Ortelli, Massimo Corbo, Ferruccio Fazio, Franco Folli

Medicine

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

We measured expression of central nervous system GABA-A receptors with ¹¹C-flumazenil (¹¹C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced ¹¹C-FMZ binding potential (BP) in motor-premotor cortex, and increased ¹¹C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.

Original language	English (US)
Pages (from-to)	1030-1033
Number of pages	4
Journal	Movement Disorders
Volume	22
Issue number	7
DOIs	https://doi.org/10.1002/mds.21441
Publication status	Published - May 15 2007

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Keywords

C- flumazenil
GABA
Positron emission tomography
Stiff person syndrome

ASJC Scopus subject areas

Neurology
Clinical Neurology

Cite this

Perani, D., Garibotto, V., Panzacchi, A., Moresco, R. M., Ortelli, P., Corbo, M., ... Folli, F. (2007). PET evidence of central GABAergic changes in stiff-person syndrome. Movement Disorders, 22(7), 1030-1033. https://doi.org/10.1002/mds.21441

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abstract = "We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.",

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AU - Moresco, Rosa Maria

AU - Ortelli, Paola

AU - Corbo, Massimo

AU - Fazio, Ferruccio

AU - Folli, Franco

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KW - Positron emission tomography

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10.1002/mds.21441