PET evidence of central GABAergic changes in stiff-person syndrome

Daniela Perani; Valentina Garibotto; Andrea Panzacchi; Rosa Maria Moresco; Paola Ortelli; Massimo Corbo; Ferruccio Fazio; Franco Folli

doi:10.1002/mds.21441

PET evidence of central GABAergic changes in stiff-person syndrome

Daniela Perani, Valentina Garibotto, Andrea Panzacchi, Rosa Maria Moresco, Paola Ortelli, Massimo Corbo, Ferruccio Fazio, Franco Folli

Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We measured expression of central nervous system GABA-A receptors with ¹¹C-flumazenil (¹¹C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced ¹¹C-FMZ binding potential (BP) in motor-premotor cortex, and increased ¹¹C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.

Original language	English (US)
Pages (from-to)	1030-1033
Number of pages	4
Journal	Movement Disorders
Volume	22
Issue number	7
DOIs	https://doi.org/10.1002/mds.21441
State	Published - May 15 2007

Keywords

C- flumazenil
GABA
Positron emission tomography
Stiff person syndrome

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "PET evidence of central GABAergic changes in stiff-person syndrome",

abstract = "We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.",

keywords = "C- flumazenil, GABA, Positron emission tomography, Stiff person syndrome",

author = "Daniela Perani and Valentina Garibotto and Andrea Panzacchi and Moresco, {Rosa Maria} and Paola Ortelli and Massimo Corbo and Ferruccio Fazio and Franco Folli",

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AU - Perani, Daniela

AU - Garibotto, Valentina

AU - Panzacchi, Andrea

AU - Moresco, Rosa Maria

AU - Ortelli, Paola

AU - Corbo, Massimo

AU - Fazio, Ferruccio

AU - Folli, Franco

PY - 2007/5/15

Y1 - 2007/5/15

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AB - We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.

KW - C- flumazenil

KW - GABA

KW - Positron emission tomography

KW - Stiff person syndrome

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