PET evidence of central GABAergic changes in stiff-person syndrome

Daniela Perani, Valentina Garibotto, Andrea Panzacchi, Rosa Maria Moresco, Paola Ortelli, Massimo Corbo, Ferruccio Fazio, Franco Folli

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We measured expression of central nervous system GABA-A receptors with 11C-flumazenil (11C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C-FMZ binding potential (BP) in motor-premotor cortex, and increased 11C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors dysfunction in SPS, possibly concurring to the motor symptoms.

Original languageEnglish (US)
Pages (from-to)1030-1033
Number of pages4
JournalMovement Disorders
Volume22
Issue number7
DOIs
StatePublished - May 15 2007

Keywords

  • C- flumazenil
  • GABA
  • Positron emission tomography
  • Stiff person syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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