Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila

Sepehr Bahadorani, Jae H. Hur, Thomas Lo, Kevin Vu, David W. Walker

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Studies in a broad spectrum of model organisms have reported that dietary restriction (DR) is associated with an increase in mitochondrial electron transport chain (ETC) function. However, the question of whether ETC function is required for DR-mediated longevity remains controversial. Here, we report that genetic and pharmacological interventions that target mitochondrial complex V affect Drosophila lifespan in a nutrient-dependent manner. These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalAging cell
Volume9
Issue number1
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • Dietary restriction
  • Drosophila
  • Electron transport chain
  • Mitochondria

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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