Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

S. Venkatesan; R. Rosenthal; N. Kanu; N. McGranahan; J. Bartek; S. A. Quezada; J. Hare; R. S. Harris; C. Swanton

doi:10.1093/annonc/mdy003

Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

S. Venkatesan, R. Rosenthal, N. Kanu, N. McGranahan, J. Bartek, S. A. Quezada, J. Hare, R. S. Harris, C. Swanton

Research output: Contribution to journal › Review article › peer-review

115 Scopus citations

Abstract

The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer.

Original language	English (US)
Pages (from-to)	563-572
Number of pages	10
Journal	Annals of Oncology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1093/annonc/mdy003
State	Published - Mar 1 2018
Externally published	Yes

Keywords

APOBEC
Drug resistance
Human immunodeficiency virus
Immune escape
Intratumour heterogeneity

ASJC Scopus subject areas

Hematology
Oncology

Access to Document

10.1093/annonc/mdy003

Cite this

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abstract = "The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer.",

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AU - Venkatesan, S.

AU - Rosenthal, R.

AU - Kanu, N.

AU - McGranahan, N.

AU - Bartek, J.

AU - Quezada, S. A.

AU - Hare, J.

AU - Harris, R. S.

AU - Swanton, C.

PY - 2018/3/1

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AB - The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer.

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KW - Drug resistance

KW - Human immunodeficiency virus

KW - Immune escape

KW - Intratumour heterogeneity

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Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

Abstract

Keywords

ASJC Scopus subject areas

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