Personalized nutrition for dementia prevention

Cécilia Samieri, Hussein N. Yassine, Debora Melo van Lent, Sophie Lefèvre-Arbogast, Ondine van de Rest, Gene L. Bowman, Nikolaos Scarmeas

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The role of nutrition has been investigated for decades under the assumption of one-size-fits-all. Yet there is heterogeneity in metabolic and neurobiological responses to diet. Thus a more personalized approach may better fit biological reality and have increased efficacy to prevent dementia. Personalized nutrition builds on the food exposome, defined as the history of diet-related exposures over the lifetime, and on its interactions with the genome and other biological characteristics (eg, metabolism, the microbiome) to shape health. We review current advances of personalized nutrition in dementia research. We discuss key questions, success milestones, and future roadmap from observational epidemiology to clinical studies through basic science. A personalized nutrition approach based on the best prescription for the most appropriate target population in the most relevant time-window has the potential to strengthen dementia-prevention efforts.

Original languageEnglish (US)
Pages (from-to)1424-1437
Number of pages14
JournalAlzheimer's and Dementia
Issue number7
StatePublished - Jul 2022


  • diet
  • exposome
  • individualized prevention
  • nutrition
  • precision medicine
  • precision nutrition
  • prevention
  • risk factors in epidemiology

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology


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