Personalized management of hyperglycemia in type 2 diabetes

Reflections from a Diabetes Care Editors' Expert Forum

Itamar Raz, Matthew C. Riddle, Julio Rosenstock, John B. Buse, Silvio E. Inzucchi, Philip D. Home, Stefano Del Prato, Ele Ferrannini, Juliana C N Chan, Lawrence A. Leiter, Derek Leroith, Ralph A Defronzo, William T. Cefalu

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia management in type 2 diabetes. This article, an outgrowth of that forum, offers a clinical translation of the underlying issues that need to be considered for effectively personalizing diabetes care. The medical management of type 2 diabetes has become increasingly complex, and its complications remain a great burden to individual patients and the larger society. The burgeoning armamentarium of pharmacological agents for hyperglycemia management should aid clinicians in providing early treatment to delay or prevent these complications. However, trial evidence is limited for the optimal use of these agents, especially in dual or triple combinations. In the distant future, genotyping and testing for metabolomic markers may help us to better phenotype patients and predict their responses to antihyperglycemic drugs. For now, a personalized ("n of 1") approach in which drugs are tested in a trial-and-error manner in each patient may be the most practical strategy for achieving therapeutic targets. Patient-centered care and standardized algorithmic management are conflicting approaches, but they can be made more compatible by recognizing instances in which personalized A1C targets are warranted and clinical circumstances that may call for comanagement by primary care and specialty clinicians.

Original languageEnglish (US)
Pages (from-to)1779-1788
Number of pages10
JournalDiabetes Care
Volume36
Issue number6
DOIs
StatePublished - Jun 2013

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Hyperglycemia
Type 2 Diabetes Mellitus
Patient-Centered Care
Precision Medicine
Metabolomics
Hypoglycemic Agents
Pharmaceutical Preparations
Primary Health Care
Pharmacology
Phenotype
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Raz, I., Riddle, M. C., Rosenstock, J., Buse, J. B., Inzucchi, S. E., Home, P. D., ... Cefalu, W. T. (2013). Personalized management of hyperglycemia in type 2 diabetes: Reflections from a Diabetes Care Editors' Expert Forum. Diabetes Care, 36(6), 1779-1788. https://doi.org/10.2337/dc13-0512

Personalized management of hyperglycemia in type 2 diabetes : Reflections from a Diabetes Care Editors' Expert Forum. / Raz, Itamar; Riddle, Matthew C.; Rosenstock, Julio; Buse, John B.; Inzucchi, Silvio E.; Home, Philip D.; Del Prato, Stefano; Ferrannini, Ele; Chan, Juliana C N; Leiter, Lawrence A.; Leroith, Derek; Defronzo, Ralph A; Cefalu, William T.

In: Diabetes Care, Vol. 36, No. 6, 06.2013, p. 1779-1788.

Research output: Contribution to journalArticle

Raz, I, Riddle, MC, Rosenstock, J, Buse, JB, Inzucchi, SE, Home, PD, Del Prato, S, Ferrannini, E, Chan, JCN, Leiter, LA, Leroith, D, Defronzo, RA & Cefalu, WT 2013, 'Personalized management of hyperglycemia in type 2 diabetes: Reflections from a Diabetes Care Editors' Expert Forum', Diabetes Care, vol. 36, no. 6, pp. 1779-1788. https://doi.org/10.2337/dc13-0512
Raz, Itamar ; Riddle, Matthew C. ; Rosenstock, Julio ; Buse, John B. ; Inzucchi, Silvio E. ; Home, Philip D. ; Del Prato, Stefano ; Ferrannini, Ele ; Chan, Juliana C N ; Leiter, Lawrence A. ; Leroith, Derek ; Defronzo, Ralph A ; Cefalu, William T. / Personalized management of hyperglycemia in type 2 diabetes : Reflections from a Diabetes Care Editors' Expert Forum. In: Diabetes Care. 2013 ; Vol. 36, No. 6. pp. 1779-1788.
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