Personality disorders are associated with more severe forms of migraine

Fang Yang, Igor Alvarenga Moreira dos Santos, Rodrigo Santiago Gomez, Arthur Kummer, Izabela Guimarães Barbosa, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


To investigate the clinical manifestation, disease course, and prognosis of migraine patients with or without personality disorders. This cross-sectional study evaluated 61 patients with migraine diagnosed according to the criteria of the International Headache Society (IHS). Personality disorders were assessed with the Structured Clinical Interview for DSM-IV (SCID-II). Migraine severity was assessed with the Headache Impact Test-6 (HIT-6). We also used a structured clinical interview to diagnose comorbid mood disorders. Of the 61 patients, 20 (32.8%) had personality disorders. Personality disorders included obsessive–compulsive 14/61 (23.0%), avoidant 6/61 (9.8%), borderline 6/61 (9.8%), paranoid 6/61 (9.8%), schizoid 2/61 (3.3%), histrionic 1/61 (1.6%) and dependent 1/61 (1.6%) types. Compared to migraine patients without personality disorders, comorbidity with any personality disorders was associated with an increased frequency of chronic migraine (p < 0.001) and more severe headache as assessed by the HIT-6 (p < 0.001). Comorbidity with personality disorders was associated with more severe forms of migraine symptoms.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalActa Neurologica Belgica
Issue number2
StatePublished - Jun 1 2019
Externally publishedYes


  • Chronic migraine
  • Obsessive–compulsive personality disorder
  • Personality disorder

ASJC Scopus subject areas

  • Clinical Neurology


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