@article{9dc10157d7fb49b8ab1c4d356ac93dbe,
title = "Person-Based Brain Morphometric Similarity is Heritable and Correlates With Biological Features",
abstract = "The characterization of the functional significance of interindividual variation in brain morphometry is a core aim of cognitive neuroscience. Prior research has focused on interindividual variation at the level of regional brain measures thus overlooking the fact that each individual brain is a person-specific ensemble of interdependent regions. To expand this line of inquiry we introduce the person-based similarity index (PBSI) for brain morphometry. The conceptual unit of the PBSI is the individual person's brain structural profile which considers all relevant morphometric measures as features of a single vector. In 2 independent cohorts (total of 1756 healthy participants), we demonstrate the foundational validity of this approach by affirming that the PBSI scores for subcortical volume and cortical thickness in healthy individuals differ between men and women, are heritable, and robust to variation in neuroimaging parameters, sample composition, and regional brain morphometry. Moreover, the PBSI scores correlate with age, body mass index, and fluid intelligence. Collectively, these results suggest that the person-based measures of brain morphometry are biologically and functionally meaningful and have the potential to advance the study of human variation in multivariate brain imaging phenotypes in healthy and clinical populations.",
keywords = "age, brain morphometry, fluid intelligence, heritability, intersubject variability",
author = "Doucet, {Gaelle E.} and Moser, {Dominik A.} and Amanda Rodrigue and Bassett, {Danielle S.} and Glahn, {David C.} and Sophia Frangou",
note = "Funding Information: National Institute of Mental Health (R01-MH104284-01A1; R01-MH116147 to S.F. and G.E.D.). National Institutes of Health (R01 MH080912 to D.C.G.). John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the Army Research Laboratory and the Army Research Office through contract numbers W911NF-10-2-0022 and W911NF-14-1-0679, the National Institute of Mental Health (R01-DC-009209-11), the National Institute of Child Health and Human Development (R01HD086888-01), the Office of Naval Research, and the National Science Foundation (BCS-1441502, BCS-1430087, NSF PHY-1554488) to D.S.B. Swiss National Science Foundation (P300PB_171584 to D.A.M.). HCP funding was provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS). HCP data are disseminated by the Laboratory of NeuroImaging at the University of California, Los Angeles. The HCP data collection and sharing was provided by the MGH-USC HCP (NIH 1U54MH091657, http://www.humanconnectome.org/; Principal Investigators: Bruce Rosen, MD, PhD; Arthur W. Toga, PhD; Van J. Weeden, MD). The CamCAN data collection and was provided by the UK Biotechnology and Biological Sciences Research Council (Grant number BB/H008217/1), together with support from the UK Medical Research Council and University of Cambridge, UK. This work was supported in part through the computational resources and staff expertise provided by Scientific Computing at the Icahn School of Medicine at Mount Sinai. Funding Information: National Institute of Mental Health (R01-MH104284-01A1; R01- MH116147 to S.F. and G.E.D.). National Institutes of Health (R01 MH080912 to D.C.G.). John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the Army Research Laboratory and the Army Research Office through contract numbers W911NF-10-2-0022 and W911NF-14-1-0679, the National Institute of Mental Health (R01-DC-009209-11), the National Institute of Child Health and Human Development (R01HD086888-01), the Office of Naval Research, and the National Science Foundation (BCS-1441502, BCS-1430087, NSF PHY-1554488) to D.S.B. Swiss National Science Foundation (P300PB-171584 to D.A.M.). HCP funding was provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS). HCP data are disseminated by the Laboratory of NeuroImaging at the University of California, Los Angeles. The HCP data collection and sharing was provided by the MGH-USC HCP (NIH 1U54MH091657, http://www.humanconnectome.org/; Principal Investigators: Bruce Rosen, MD, PhD; Arthur W. Toga, PhD; Van J. Weeden, MD). The CamCAN data collection and was provided by the UK Biotechnology and Biological Sciences Research Council (Grant number BB/H008217/1), together with support from the UK Medical Research Council and University of Cambridge, UK. This work was supported in part through the computational resources and staff expertise provided by Scientific Computing at the Icahn School of Medicine at Mount Sinai. Publisher Copyright: {\textcopyright} The Author(s) 2018.",
year = "2019",
month = feb,
day = "1",
doi = "10.1093/cercor/bhy287",
language = "English (US)",
volume = "29",
pages = "852--862",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "2",
}