TY - JOUR
T1 - Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction
AU - Torres, Karen Cecília de Lima
AU - Rocha, Natália Pessoa
AU - de Rezende, Vítor Bortolo
AU - Dutra, Walderez Ornelas
AU - Gollob, Kenneth John
AU - Cardoso, Francisco
AU - Teixeira, Antonio Lucio
N1 - Publisher Copyright:
© 2016, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.
PY - 2016/1
Y1 - 2016/1
N2 - The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.
AB - The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.
KW - Autoimmunity
KW - B1 cells
KW - Lymphocytes
KW - Sydenham chorea
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U2 - 10.1590/0004-282X20150179
DO - 10.1590/0004-282X20150179
M3 - Article
C2 - 26486494
AN - SCOPUS:84958057010
SN - 0004-282X
VL - 74
SP - 5
EP - 9
JO - Arquivos de neuro-psiquiatria
JF - Arquivos de neuro-psiquiatria
IS - 1
ER -