Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfunction

Karen Cecília de Lima Torres, Natália Pessoa Rocha, Vítor Bortolo de Rezende, Walderez Ornelas Dutra, Kenneth John Gollob, Francisco Cardoso, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalArquivos de neuro-psiquiatria
Issue number1
StatePublished - Jan 2016
Externally publishedYes


  • Autoimmunity
  • B1 cells
  • Lymphocytes
  • Sydenham chorea

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry


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