Persistent acute inflammation at the implant-abutment interface

N. Broggini, L. M. McManus, J. S. Hermann, R. U. Medina, T. W. Oates, R. K. Schenk, D. Buser, J. T. Mellonig, D. L. Cochran

Research output: Contribution to journalArticlepeer-review

344 Scopus citations


The inflammatory response adjacent to implants has not been well-investigated and may influence peri-implant tissue levels. The purpose of this study was to assess, histomorphometrically, (1) the timing of abutment connection and (2) the influence of a microgap. Three implant designs were placed in the mandibles of dogs. Two-piece implants were placed at the alveolar crest and abutments connected either at initial surgery (non-submerged) or three months later (submerged). The third implant was one-piece. Adjacent interstitial tissues were analyzed. Both two-piece implants resulted in a peak of inflammatory cells approximately 0.50 mm coronal to the microgap and consisted primarily of neutrophilic polymorphonuclear leukocytes. For one-piece implants, no such peak was observed. Also, significantly greater bone loss was observed for both two-piece implants compared with one-piece implants. In summary, the absence of an implant-abutment interface (microgap) at the bone crest was associated with reduced peri-implant inflammatory cell accumulation and minimal bone loss.

Original languageEnglish (US)
Pages (from-to)232-237
Number of pages6
JournalJournal of dental research
Issue number3
StatePublished - Mar 2003


  • Microgap
  • Neutrophil
  • One-piece implant
  • Peri-implant inflammation
  • Two-piece implant

ASJC Scopus subject areas

  • General Dentistry


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