TY - JOUR
T1 - Persistence of flavor neophobia as an indicator of state-dependent retention induced by pentobarbital, stress, and estrus
AU - Morilak, David A.
AU - Orndoff, Robert K.
AU - Riccio, David C.
AU - Richardson, Rick
N1 - Funding Information:
State-dependent retention (SDR), or dissociated learning, has received a great deal of experimental attention in the past two decades. Basically, This research was supported in part by funding from the Psychology Department at Muskingum College to R. K. Orndoff, NIMH Grant MH30223 to D. C. Riccio, and by an NSF Undergraduate Research Participation Grant (NSF SPI 8025709) to Kent State University in which D. Morilak was the participant. Preliminary investigation commenced at Muskingum College, Experiments 1 and 2 were conducted in the Psychology Department at Ken.*. State University, and Experiment 3 in the Psychology Department at Muskingum College.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1983/5
Y1 - 1983/5
N2 - As fear conditioning paradigms have failed to find state-dependent retention (SDR) in rats dissociated by the estrous state, an attempt was made to establish a paradigm involving the attenuation of flavor neophobia as a more sensitive indicator of SDR. Experiment 1 established that the paradigm did indicate SDR in male rats dissociated by pentobarbital (10 mg/kg). Experiment 2 generalized the utility of the technique by employing an endogenous state, shock-induced stress, as the dissociative state. Having proved to be an indicator of SDR in the first two experiments, the technique was used in Experiment 3 to investigate the possible dissociative characteristics of the estrous state in female rats. Estrus was investigated because, due to the hormonal condition during estrus, it may provide a useful tool in investigating the dissociative aspects of human perimenstrual periodic psychosis. In Experiment 3, using ovariectomized female rats brought into estrus by injection of estrogen and progesterone in a sequence and amount comparable to the natural cycle, estrus was not demonstrated to be dissociative, i.e., did not produce SDR. The implications of these results in relation to perimenstrual periodic psychosis were discussed.
AB - As fear conditioning paradigms have failed to find state-dependent retention (SDR) in rats dissociated by the estrous state, an attempt was made to establish a paradigm involving the attenuation of flavor neophobia as a more sensitive indicator of SDR. Experiment 1 established that the paradigm did indicate SDR in male rats dissociated by pentobarbital (10 mg/kg). Experiment 2 generalized the utility of the technique by employing an endogenous state, shock-induced stress, as the dissociative state. Having proved to be an indicator of SDR in the first two experiments, the technique was used in Experiment 3 to investigate the possible dissociative characteristics of the estrous state in female rats. Estrus was investigated because, due to the hormonal condition during estrus, it may provide a useful tool in investigating the dissociative aspects of human perimenstrual periodic psychosis. In Experiment 3, using ovariectomized female rats brought into estrus by injection of estrogen and progesterone in a sequence and amount comparable to the natural cycle, estrus was not demonstrated to be dissociative, i.e., did not produce SDR. The implications of these results in relation to perimenstrual periodic psychosis were discussed.
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U2 - 10.1016/S0163-1047(83)90369-2
DO - 10.1016/S0163-1047(83)90369-2
M3 - Article
C2 - 6684918
AN - SCOPUS:0021084043
VL - 38
SP - 47
EP - 60
JO - Communications in behavioral biology. Part A: [Original articles]
JF - Communications in behavioral biology. Part A: [Original articles]
SN - 1074-7427
IS - 1
ER -