Abstract
As fear conditioning paradigms have failed to find state-dependent retention (SDR) in rats dissociated by the estrous state, an attempt was made to establish a paradigm involving the attenuation of flavor neophobia as a more sensitive indicator of SDR. Experiment 1 established that the paradigm did indicate SDR in male rats dissociated by pentobarbital (10 mg/kg). Experiment 2 generalized the utility of the technique by employing an endogenous state, shock-induced stress, as the dissociative state. Having proved to be an indicator of SDR in the first two experiments, the technique was used in Experiment 3 to investigate the possible dissociative characteristics of the estrous state in female rats. Estrus was investigated because, due to the hormonal condition during estrus, it may provide a useful tool in investigating the dissociative aspects of human perimenstrual periodic psychosis. In Experiment 3, using ovariectomized female rats brought into estrus by injection of estrogen and progesterone in a sequence and amount comparable to the natural cycle, estrus was not demonstrated to be dissociative, i.e., did not produce SDR. The implications of these results in relation to perimenstrual periodic psychosis were discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 47-60 |
| Number of pages | 14 |
| Journal | Behavioral and Neural Biology |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
Cite this
Persistence of flavor neophobia as an indicator of state-dependent retention induced by pentobarbital, stress, and estrus. / Morilak, David A; Orndoff, Robert K.; Riccio, David C.; Richardson, Rick.
In: Behavioral and Neural Biology, Vol. 38, No. 1, 1983, p. 47-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persistence of flavor neophobia as an indicator of state-dependent retention induced by pentobarbital, stress, and estrus
AU - Morilak, David A
AU - Orndoff, Robert K.
AU - Riccio, David C.
AU - Richardson, Rick
PY - 1983
Y1 - 1983
N2 - As fear conditioning paradigms have failed to find state-dependent retention (SDR) in rats dissociated by the estrous state, an attempt was made to establish a paradigm involving the attenuation of flavor neophobia as a more sensitive indicator of SDR. Experiment 1 established that the paradigm did indicate SDR in male rats dissociated by pentobarbital (10 mg/kg). Experiment 2 generalized the utility of the technique by employing an endogenous state, shock-induced stress, as the dissociative state. Having proved to be an indicator of SDR in the first two experiments, the technique was used in Experiment 3 to investigate the possible dissociative characteristics of the estrous state in female rats. Estrus was investigated because, due to the hormonal condition during estrus, it may provide a useful tool in investigating the dissociative aspects of human perimenstrual periodic psychosis. In Experiment 3, using ovariectomized female rats brought into estrus by injection of estrogen and progesterone in a sequence and amount comparable to the natural cycle, estrus was not demonstrated to be dissociative, i.e., did not produce SDR. The implications of these results in relation to perimenstrual periodic psychosis were discussed.
AB - As fear conditioning paradigms have failed to find state-dependent retention (SDR) in rats dissociated by the estrous state, an attempt was made to establish a paradigm involving the attenuation of flavor neophobia as a more sensitive indicator of SDR. Experiment 1 established that the paradigm did indicate SDR in male rats dissociated by pentobarbital (10 mg/kg). Experiment 2 generalized the utility of the technique by employing an endogenous state, shock-induced stress, as the dissociative state. Having proved to be an indicator of SDR in the first two experiments, the technique was used in Experiment 3 to investigate the possible dissociative characteristics of the estrous state in female rats. Estrus was investigated because, due to the hormonal condition during estrus, it may provide a useful tool in investigating the dissociative aspects of human perimenstrual periodic psychosis. In Experiment 3, using ovariectomized female rats brought into estrus by injection of estrogen and progesterone in a sequence and amount comparable to the natural cycle, estrus was not demonstrated to be dissociative, i.e., did not produce SDR. The implications of these results in relation to perimenstrual periodic psychosis were discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021084043&partnerID=8YFLogxK
U2 - 10.1016/S0163-1047(83)90369-2
DO - 10.1016/S0163-1047(83)90369-2
M3 - Article
C2 - 6684918
AN - SCOPUS:0021084043
VL - 38
SP - 47
EP - 60
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
SN - 1074-7427
IS - 1
ER -