Peritubular capillary rarefaction: A new therapeutic target in chronic kidney disease

Yujiro Kida, Bie Nga Tchao, Ikuyo Yamaguchi

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Chronic kidney disease (CKD) has reached worldwide epidemic proportions and desperately needs new therapies. Peritubular capillary (PTC) rarefaction, together with interstitial fibrosis and tubular atrophy, is one of the major hallmarks of CKD and predicts renal outcome in patients with CKD. PTC endothelial cells (ECs) undergo apoptosis during CKD, leading to capillary loss, tissue hypoxia, and oxidative stress. Although the mechanisms of PTC rarefaction are not well understood, the process of PTC rarefaction depends on multiple events that occur during CKD. These events, which lead to an antiangiogenic environment, include deprivation of EC survival factors, increased production of vascular growth inhibitors, malfunction of ECs, dysfunction of endothelial progenitor cells, and loss of EC integrity via pericyte detachment from the vasculature. In this review, we focus on major factors regulating angiogenesis and EC survival and describe the roles of these factors in PTC rarefaction during CKD and possible therapeutic applications.

Original languageEnglish (US)
Pages (from-to)333-342
Number of pages10
JournalPediatric Nephrology
Volume29
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

Keywords

  • Angiogenesis
  • Angiogenic growth factors
  • CKD
  • Endothelial cell
  • Pericytes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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