Peripheral vasopressin for safe and adequate control of portal hypertension during shunt operations

Kenneth R. Sirinek, Edward W. Martin, Neil R. Thomford

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Nine patients with cirrhosis and portal hypertension were given intraoperative vasopressin (40 U/hr) in a continuous peripheral infusion during establishment of a distal splenorenal shunt. In all patients a significant and sustained reduction in portal venous pressure was achieved. As a result, blood loss during dissection and the time required for operation were minimized. The expected vasopressin-induced reduction in cardiac output was limited to a transient decrease at 5 minutes. There were no significant cardiac arrhythmias. These results suggest that vasopressin given through a peripheral vein during shunt operations is safe and facilitates dissection by providing significant and sustained reductions in portal venous pressure.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalThe American Journal of Surgery
Volume131
Issue number1
DOIs
StatePublished - Jan 1976
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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